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  • 1
    Electronic Resource
    Electronic Resource
    Comparative bioavailability of two different rectal preparations of piroxicam in man (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 315-317 
    Details
    ISSN: 1432-1041
    Keywords: Piroxicam, NSAID ; suppository, bioavailability, pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A comparative pharmacokinetic study was performed with two types of suppository each containing 20 mg piroxicam. The bioavailability of piroxicam was studied in 24 healthy volunteers in a double blind, randomised, cross over study. No significant difference was found in the pharmacokinetic parameters [AUC(0–72 h), AUC, Cmax, t1/2β calculated from plasma concentration time curves, indicating that the two preparations were bioequivalent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02333031
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A new validated high-performance liquid chromatographic method for the determination of EGIS-9933 in rat plasma (1998)
    Springer
    Chromatographia 48 (1998), S. 158-162 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; EGIS-9933 ; Solid phase extraction ; Rat plasma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A new highly sensitive high-performance liquid chromatographic (HPLC) procedure for determination of EGIS-9933 (a newly developed anxiolytic compound) in rat plasma is described. A gradient, elution method with UV detection at 270 nm has been developed using a mobile phase of a mixture of A: methanol:acetonitrile 1:9 and B:0.5% triethilamine in water, the pH of B was adjusted to 3 with phosphoric acid. Solid phase extraction (SPE) was used for the sample preparation. The calibration was linear in the 10–10000 ng mL−1 concentration range. The limit of quantification was 10 ng mL−1. The bioanalytical method was validated according to internationally accepted criteria for biological samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02467535
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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