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  • 1
    Electronic Resource
    Electronic Resource
    Demonstration by degeneration silver method of the ascending projection from the locus ceruleus (1974)
    Springer
    Experimental brain research 20 (1974), S. 181-192 
    Details
    ISSN: 1432-1106
    Keywords: Locus ceruleus ; Cerulo-cortical tract ; Ascending reticular fiber ; Rat ; Fink-Heimer method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to demonstrate the ascending projection from the locus ceruleus by degeneration silver method, the nucleus was destroyed unilaterally in rats and the brains were stained by a modified Fink-Heimer method following various survival times. Additional experiments included the bilateral destruction of the locus ceruleus and the administration of 6-OH-DOPA. For the demonstration of degenerated terminals in the cerebral cortex it is essential to choose an optimal survival time of 4 or 5 days, keep the time of fixation below 1 week, and perform treatments with permanganate and with silver at 37°C. The trajectory and distribution of the cerulo-cortical tract as revealed by the silver degeneration methods is in agreement with the results of the histofluorescence method, with some minor differences. The ascending fibers run through Forel's tegmental fascicle, turn rostro-ventrally to the subthalamus, enter and cross the internal capsule, pass through the ventral part of the caudate-putamen and distribute to the entire cerebral cortex. The tract is mainly ipsilateral, though some fibers are crossing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234012
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Demonstration of [d-Ala^2]deltorphin I-like immunoreactivity in mucosal epithelial cells of the rat gastrointestinal tract
    Amsterdam : Elsevier
    Peptides 15 (1994), S. 1095-1100 
    Details
    ISSN: 0196-9781
    Keywords: Deltorphin ; Electron microscopy ; Gut ; Immunocytochemistry ; Rat ; δ-Opioid receptors
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0196-9781(94)90076-0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Vitamin B6 phototoxicity induced by UVA radiation (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 562-567 
    Details
    ISSN: 1432-069X
    Keywords: Keywords Vitamin B6 ; UVA ; Phototoxicity ; ESR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have previously reported that pyridoxine shows UVA-induced cytotoxicity. Four other vitamin B6 compounds (pyridoxal, pyridoxamine, pyridoxal phosphate, and pyridoxamine phosphate) are metabolically more important in vivo than pyridoxine. These compounds were examined for UVA phototoxicity to cultured human fibroblasts. The cytotoxicity was measured by post-UVA irradiation colony-forming ability. All the B6 compounds except pyridoxal phosphate showed cytotoxicity. Pyridoxamine phosphate, which is the most important form of vitamin B6 in vivo, had the strongest cytotoxic effect. To examine the involvement of reactive oxygen species in the phototoxicity, we performed an electron spin resonance study using the spin trapping agent, 5,5-dimethyl-1-pyrroline N-oxide, and diethylenetriaminepentaacetic acid. We failed to detect radicals derived from vitamin B6. The cytotoxic effect remained in UVA-irradiated solutions for at least 30 min after the end of UVA irradiation. Hydrogen peroxide was produced in the solution, but the amount was not enough to cause cytotoxicity. In addition, the cells from xeroderma pigmentosum patients who belong to group A or C showed survival curves similar to those of normal fibroblasts. This suggests that cyclobutane pyrimidine dimers or 6-4 photoproducts of DNA were not involved in this damage. These findings suggest that UVA-induced vitamin B6 cytotoxicity is caused by toxic photoproducts resulting from irradiated vitamin B6.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030000174
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    ESR spectrometer with a wide frequency range using a gyrotron as a radiation power source (1995)
    Springer
    International journal of infrared and millimeter waves 16 (1995), S. 293-305 
    Details
    ISSN: 1572-9559
    Keywords: gyrotron ; ESR ; wide frequency range
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The development of a high frequency electron spin resonance (ESR) spectrometer with a wide frequency range using a gyrotron as the radiation power source is described. GYROTRON FU-E, optimized for use in an ESR spectrometer in the millimeter wave range, was developed in Fukui University. In order to test the normal operation of the spectrometer, the ESR of two standard samples, single crystal and polycrystalline DPPH, has been measured, in the pulsed mode over the frequency range from 65 GHz to 135 GHz.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02085864
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Noradrenergic axon terminals in the substantia gelatinosa of the rat spinal cord (1982)
    Springer
    Cell & tissue research 222 (1982), S. 359-378 
    Details
    ISSN: 1432-0878
    Keywords: Axon terminals ; Substantia gelatinosa ; Spinal cord ; Noradrenaline ; Ultrastructure ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The noradrenergic terminals in the substantia gelatinosa of the dorsal horn of the cervical spinal cord of the rat were investigated by means of the histofluorescence technique and electron-microscopic cytochemistry using the glyoxylic acid-KMnO4 fixation technique. In accordance with the topographical distribution of fluorescent catecholaminergic fibers, noradrenergic terminals containing small granular vesicles were frequently observed electron microscopically in the outer layer of the substantia gelatinosa. These terminals were most frequently found to appose without showing typical synaptic features, small-caliber dendrites, spine apparatus, and rarely, large caliber dendrites. Only in a few cases, the noradrenergic terminals exhibited typical synaptic contacts with dendritic elements of small size. In addition, noradrenergic terminals apposed non-noradrenergic terminals containing small agranular vesicles. In rats bearing surgical lesions of the dorsal roots, no noradrenergic terminal were found in contact with the degenerated axon terminals in the substantia gelatinosa. These findings suggest that the noradrenergic afferents to the substantia gelatinosa may exert their influence on sensory transmission via dorsal horn cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00213218
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    Paper (German National Licenses)
    Fulltext
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