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  • 1
    Electronic Resource
    Electronic Resource
    No disturbance of myelination in the central nervous system by selective3Hβ-irradiation (1987)
    Springer
    Acta neuropathologica 72 (1987), S. 402-405 
    Details
    ISSN: 1432-0533
    Keywords: Myelin ; Effects of radiation ; Spinal cord ; Tritium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of a selective irradiation of myelin by3H β-particles was studied by light and electron microscopic methods in guinea pig spinal cord. The animals were injected with [3H]leucine shortly after birth when the rate of myelin biosynthesis is high and sacrificed 130 days later. In spinal cord the radioactivity was mainly preserved in myelin because the half life of myelin proteins is much higher than that of most other CNS protein. As a consequence the irradiation dose in the white matter was much higher than in the gray matter. In myelin internally irradiated by3H β-particles within 130 days at a dose of 10 Gy no alterations could be detected either by morphological or by morphometric methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687273
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Decreased cAMP content of the hypothalamus of genetically hypertensive rats (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 302 (1978), S. 341-343 
    Details
    ISSN: 1432-1912
    Keywords: Cyclic AMP ; Hypothalamus ; Genetically hypertensive rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In genetically hypertensive rats an altered catecholamine content of hypothalamic structures has been reported. In the present study cAMP was estimated in the hypothalamus and cortex of genetically hypertensive rats and compared with normotensive controls of the same strain. It is shown, that the cAMP content of the hypothalamus of the hypertensive animals was decreased to about 60% of control values, whereas there was no difference of the cAMP content in the cortical regions of the same animals. These results indicate an alteration of the adenyl cyclase-cAMP-phosphodiesterase system in hypothalamic structures of genetically hypertensive rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508306
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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