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  • 1
    ISSN: 1420-9071
    Keywords: Gigantecin ; acetogenins ; Goniothalamus giganteus ; Annonaceae ; brine shrimp ; antimitotic ; cytotoxic ; crown gall tumors ; potato disc assay ; 9 ASK
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Gigantecin (I), a novel tetrahydroxy-di-tetrahydrofuran fatty acid γ-lactone (acetogenin), was isolated from an ethanolic extract of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae), by means of activity-directed fractionation (brine shrimp lethality test). This new compound is extremely cytotoxic to human tumor cells, inhibits crown gall tumors on potato discs, and is active in an assay designed to detect antimitotic agents (9 ASK).
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1420-9071
    Keywords: Goniothalamicin ; annonacin ; acetogenins ; Goniothalamus giganteus ; Annonaceae ; brine shrimp ; insecticidal ; cytotoxic ; antileukemic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Using brine shrimp lethality for activity-directed fractionation, goniothalamicin (I), a new tetrahydroxy-mono-tetrahydrofuran fatty acid γ-lactone (acetogenin), has been isolated from ethanolic extracts of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae). This novel compound was found to be cytotoxic and insecticidal and inhibited the formation of crown gall tumors on potato discs. Annonacin (II), the only other reported mono-tetrahydrofuran acetogenin, was also isolated; the previously reported 9ASK (astrocytoma reversal) activity ofII was confirmed, andII is now also found to be weakly active against 3PS murine leukemia.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1420-9071
    Keywords: Sylvaticin ; acetogenin ; Rollinia sylvatica ; Annonaceae ; brine shrimp ; cytotoxicity ; insecticidal ; striped cucumber beetle ; European corn borer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Sylvaticin (I), a new tetrahydroxy annonaceous acetogenin with nonadjacent tetrahydrofuran rings, has been isolated from the dried fruits ofRollinia sylvatica St. Hil. (Annonaceae). This compound is extremely cytotoxic to human tumor cells and shows promising insect control properties.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 43 (1987), S. 947-949 
    ISSN: 1420-9071
    Keywords: Annonacin ; polyketide ; Annona densicoma ; Annonaceae ; biological activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new linear polyketide, Annonacin (I), has been isolated from active extracts of the stembark ofAnnona densicoma Mart. Annonacin (I) is highly cytotoxic and is active in an assay designed to detect antimitotic agents. The structure of (I) was determined by analysis of spectroscopic data.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 7 (1973), S. 137-154 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper shows how analytic surfaces can be used to define the vanes of an impeller of a centrifugal compressor. The analysis has been given of a cubic-linear patch for representing three-dimensional geometries. An example has shown how this type of patch can be successfully used to model the geometry of centrifugal or mixed flow impellers having 'swept back vanes at the outlet.The analysis has been programmed for the Atlas computer at the Computer Aided Design Centre (CADC), Cambridge and set up in such a way that the designer can examine systematically a range of impeller shapes.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 20 (1996), S. 457-488 
    ISSN: 0363-9061
    Keywords: Linear thermo-poro-elastic materials ; boundary element method ; Green's functions ; Dirac delta functions ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: This paper presents a direct boundary element method of numerical analysis, formulated in the Laplace transform domain, for a plane strain analysis of a linear thermo-poro-elastic material consolidating in the presence of a heat source. The equations governing the behaviour of the material are assumed to be a set of self-adjoint and fully coupled linear equations. A physical intepretation of the constants appearing in the linear theory relevant to engineering applications is presented. A boundary integral equation is developed from the governing equations in a straightforward way using the properties of Dirac delta functions, and an approximate boundary element method of numerical analysis is implemented using the Green's functions derived previously by the authors. The numerical analysis presented is motivated by the engineering design of a heat generating radioactive waste repository located deep underground. For this reason, there is a description of the application of the boundary integral equation method presented to the numerical solution of several problems of theoretical and practical interest in the area of radioactive waste disposal in clay-like soils.
    Additional Material: 20 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 13 (1989), S. 283-302 
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: A simple and efficient method for the solution of uncoupled transient thermoelastic problems using boundary integral techniques is presented. The method employs a Laplace transformation to remove temporarily the time dependence of the governing equations. Numerical analysis is then carried out in the transform space, and results in the time-position space are found by numerical inversion of the Laplace transform. The method has the advantage that it avoids time-stepping and the costly evaluation of domain integrals. Boundary element and analytic solutions are compared, and the effect of cooling on the stresses around a deep underground opening is examined.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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