Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Ambient and biochemical effect monitoring of workers exposed to ethylene oxide (1998)
    Springer
    International archives of occupational and environmental health 71 (1998), S. 14-18 
    Details
    ISSN: 1432-1246
    Keywords: Key words Ambient monitoring ; Biological monitoring ; Biochemical effect monitoring ; Protein adducts ; Ethylene oxide ; N-Alkyl-Edman method ; N-2-Hydroxyethylvaline ; Sterilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: Ethylene oxide is an alkylating agent known to be a directly acting mutagen and carcinogen. This study describes the relationship between workplace ambient air concentrations of ethylene oxide and the concentration of N-2-hydroxyethylvaline in the globin of exposed workers. Methods: During the sterilization of medical equipment, 12 workers were occupationally exposed to ethylene oxide. Personal and stationary ambient air measurements were carried out to monitor the external exposure. The determination of the protein adducts was based on the N-alkyl-Edman method, introducing a new commercially available dipeptide standard for calibration purposes. Results: Ethylene oxide concentrations ranging from 0.2 to 8.5 ppm were found in the workplace air. The adduct concentrations ranged from 5,219 to 32,738 pmol N-2-hydroxyethylvaline/g globin in the case of regularly exposed workers (n = 9) and from 518 to 3,321 pmol N-2-hydroxyethylvaline/g globin for three persons with occasional contact with ethylene oxide. Conclusions: The Deutsche Forschungsgemeinschaft established in 1993 a relationship between the ethylene oxide concentration in ambient air and the amount of N-2-hydroxyethylvaline in human globin. By extrapolation, constant exposure to 1 ppm ethylene oxide should yield approximately 4,000 pmol N-2-hydroxyethylvaline/g globin. The ambient air concentrations of ethylene oxide and the amount of N-2-hydroxyethylvaline determined within the present study confirm this extrapolation in practice. In addition, the determination of adducts based on the use of commercially available dipeptide standards for calibration purposes turned out to be an advantageous alternative to the commonly used protein standards.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004200050244
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    26. Intraluminale Bestrahlung mit Iridium 192 —ein neuer Weg zur Behandlung inoperabler Oesophaguscarcinome? (1985)
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 169-171 
    Details
    ISSN: 1435-2451
    Keywords: Esophageal carcinoma ; Palliative therapy ; Iridium 192-afterloading ; Oesophaguscarcinom ; Palliativtherapie ; Iridium 192 ; Afterloading
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Beim inoperablen Oesophaguscarcinom wurde als neues Alternativverfahren gegenüber der Palliativresektion die intraluminale hochdosierte Afterloadingtherapie mit Iridium 192 angewandt. Voraussetzung für dieses Verfahren, das im letzten Jahr bei 19 Patienten eingesetzt wurde, ist die vorhergehende laserendoskopische Passagewiederherstellung der Tumorstenose. In 2wöchigen Abständen wird bis zu 3mal endocavitär mit einer Dosis von 7 Gy bestrahlt. Bei kontinuierlicher endoskopischer Patientenüberwachung ist die Tubusimplantation bei besserer Lebensqualität und vergleichbaren Überlebenszeiten vermeidbar.
    Notes: Summary In inoperable esophageal carcinoma the intraluminal high dose afterloading therapy with Iridium 192 was employed as an alternative to the palliative resection. Prerequisite for this treatment, which was used in 19 patients during the last year, is the preceding passage restoration of the tumor stenosis by endoscopic laser therapy Every two weeks the patients are endocavitarily irradiated up to 3 times with a dose of 7 Gy. Observing the patients by endoscopic means the implantation of a tubus is avoidable achieving better quality of life and comparable survival times.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01836626
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...