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Digitale Medien

Granular cell brain tumors of the laboratory rat: an immunohistochemical approach (1991)

Perentes, E. ; Maraziotis, T. ; Qureshi, S. R.

Springer

Acta neuropathologica 82 (1991), S. 112-117

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ISSN: 1432-0533

Schlagwort(e): Rat brain tumors ; Granular cell tumors ; Immunohistochemistry ; Astrocytoma

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary We have studied paraffin-embedded specimens of 17 rat granular cell brain tumors (GCBT) from four long-term drug safety carcinogenicity studies by peroxidase-antiperoxidase (PAP) immunohistochemistry with either polyvalent or monoclonal antibodies against glial fibrillary acidic protein (GFAP), S-100 protein (S-100), Leu-7 epitopes, vimentin (VIM), keratin, desmin, and myelin basic protein. We have found that 9 of the 17 GCBT contained GFAP-positive, S-100-positive, and VIM-positive astrocytes, while GFAP-positive and VIM-positive granular cells were observed in 5 of these 9 tumors. Our findings indicate that astroglial cells are involved in rat GCBT and suggest that an astrocytic origin should be considered for these neoplasms.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00293953

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Digitale Medien

Non-specific binding of mouse myeloma IgM immunoglobulins by human myelin sheaths and astrocytes (1986)

Perentes, E. ; Rubinstein, L. J.

Springer

Acta neuropathologica 70 (1986), S. 284-288

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ISSN: 1432-0533

Schlagwort(e): Myelin sheaths ; Astroglial cells ; Mouse IgM ; GFAP ; Monoclonal antibodies

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The immunoreactivity of purified mouse myeloma IgM immunoglobulins (mouse IgM) to human myelin sheaths and astroglial cells was evaluated with the peroxidase-antiperoxidase method on paraffin-embedded tissues from human gliomas and areas of multiple sclerosis, and from normal human cerebrum, spinal cord and spinal nerve roots. The mouse IgM reacted positively with central and peripheral myelin sheaths and, as shown independently by others, with the cytoplasm of neoplastic and reactive astroglia. Parallel immunostaining of successive sections with an anti-glial fibrillary acidic protein (GFAP) serum and/or the anti-Leu 7 monoclonal antibody was of considerable assistance in identifying the immunoreactive elements and in distinguishing specific from non-specific immunostaining of myelin sheaths and astroglia. Pretreatment with normal human serum inhibited the non-specific binding by mouse IgM without altering GFAP and Leu 7 reactivities. The non-specific binding of mouse IgM to human myelin sheaths and astroglia can therefore be overcome, and the specificity of mouse IgM monoclonal antibodies retained, by the parallel immunostaining of successive sections with mouse IgM. If nonspecific binding by mouse IgM is found to occur, it can then be inhibited by preincubation with normal human serum without loss of specific antigenicity.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00686085

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Digitale Medien

Polymyositis with severe facial involvement (1982)

Bogousslavsky, J. ; Perentes, E. ; Regli, F. ; [weitere]

Springer

Journal of neurology 228 (1982), S. 277-281

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ISSN: 1432-1459

Schlagwort(e): Facial palsy ; Polymyositis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Beschreibung / Inhaltsverzeichnis: Zusammenfassung Wir berichten über einen Fall einer entzündlichen Myopathie mit fazio-pharyngo-proximaler Beteiligung. Fazialisparese als wichtigstes Zeichen ist ungewöhnlich im Rahmen einer Polymyositis. Die besondere Verteilung der Muskelschwäche, welche unsere Patientin aufwies, ist eine klinische Variante, bei welcher immer nach einem entzündlichen Prozeß gesucht werden muß, da eine Steroidtherapie hier mit Erfolg angewendet werden kann.

Notizen: Summary A case of imflammatory myopathy with faciopharyngoproximal distribution is reported. It is very unusual for facial weakness to be a major feature in polymyositis, but when other muscles are involved the clinician should be stimulated to look for an inflammatory myopathy. Marked improvement may be achieved as a result of corticosteroid therapy.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00313418

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