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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 255 (1994), S. 141-146 
    ISSN: 1432-0711
    Keywords: Fallopian tube carcinoma ; Stage 0 ; Stage I ; Chemotherapy ; Irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To evaluate retrospectively the importance of invasion beyond the basement membrane on overall survival in Fallopian tube carcinoma and its influence on the necessity of postoperative adjuvant therapy (stage 0 vs. stage I).Design: In a nationwide analysis the data of 51 patients were evaluated. The participating departments provided the study center with histologic specimens. A re-staging was done according to the FIGO-classification for Fallopian tube carcinomas. Stage 0 patients received no further postoperative therapy, in stage I patients were devided in 2 groups to evaluate the impact of postoperative adjuvant therapy (chemotherapy vs. irradiation).Results: Patients of stage 0 had a significantly better prognosis than patients of stage I (p=0.035). Stage I patients treated by irradiation showed a significantly better prognosis than patients treated by chemotherapy (p=0.017).Conclusion: Tumour penetration through the basement membrane causes prognosis to deteriorate significantly (5-year survival rate about 50% in stage I). Postoperative therapy is thus indicated with stage I disease. Irradiation seems to give better results than chemotherapy.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0711
    Keywords: Fallopian tube carcinoma ; CA-125 serum levels ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Levels of CA-125 were determined pre- and postoperatively in 13 patients with Fallopian tube cancer. Values before surgery were significantly higher (Median 1220 IU/ml, 90–5000 IU/ml) compared with postoperative levels (Median 194 IU/ml, 67–880 IU/ml) (P=0.0052). Correlation analysis with FIGO stage and grading failed to show any statistical significance, but a trend for a positive correlation with FIGO stage and preoperative values could be observed. The CA-125 antigen is expressed by Fallopian tube carcinoma and should therefore be used in diagnosis and follow-up.
    Type of Medium: Electronic Resource
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