ISSN:
1432-0533
Schlagwort(e):
Freeze fracture
;
Muscle plasma membrane
;
Cholesterol
;
Fukuyama-type congenital muscular dystrophy
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary We used digitonin in freeze-fracture analysis of the muscle plasma membrane cholesterol content in six patients with Fukuyama-type congenital muscular dystrophy and six control children. A significantly greater proportion of surface area was taken up by digitonin-cholesterol complexes in the patients (51.2%±4.7%) than in controls (31.9%±2.9%) (P〈0.01). Since membrane cholesterol has a dynamic regulatory function in affecting the activity of membrane-bound proteins, the increased cholesterol content in the patients suggests a functional abnormality of the muscle plasma membrane in this disease.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00686792
Permalink