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  • 1
    Electronic Resource
    Electronic Resource
    Vergleichende Hämolyseversuche an Meerschweinchen- und Rattenerythrocyten in vitro mit Phospholipase A und Direkt-Lytischem-Faktor aus Cobragift (Naja naja) (1971)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 268 (1971), S. 27-32 
    Details
    ISSN: 1432-1912
    Keywords: Haemolysis ; Guinea-Pig Erythrocytes ; Rat Erythrocytes ; Phospholipase A ; Direct Lytic Factor ; Cobra Venom ; HÄmolyse ; Meerschweinchenerythrocyten ; Rattenery-throcyten ; Phospholipase A ; Direkt Lytischer Faktor ; Cobragift
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. At high concentrations phospholipase A of cobra venom has a direct haemolytic action on washed guinea-pig red cells. The concentration necessary for this effect is one hundred times higher than that required for haemolysis in the presence of the direct lytic factor (DLF). 2. Like guinea-pig red cells, rat erythrocytes are lysed by DLF, but are much less sensitive. A potentiation of haemolysis by the combined action of Phospholipase A and DLF is also seen in rat erythrocytes. Concentrations of DLF 50 times higher and of Phospholipase A 100 times higher than used for guinea-pig red cells are necessary to obtain comparable degrees of haemolysis with rat erythrocytes. 3. The degree of potentiated haemolysis depends on both, the concentration of DLF and the concentration of Phospholipase A. The different susceptibility of red cells from different species to haemolysis by cobra venom thus does not depend on a different sensitivity to one of the two haemolysins alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997170
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Use of saliva in monitoring carbamazepine medication in epileptic children (1977)
    Springer
    European journal of pediatrics 126 (1977), S. 37-44 
    Details
    ISSN: 1432-1076
    Keywords: Salivary carbamazepine level ; Enzyme immunoassay ; Carbamazepine saliva/serum ratio ; Drug monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 17 children on carbamazepine medication alone and 15 children on combined drug regimens, carbamazepine levels were determined in paired samples of serum and mixed saliva by enzyme immunoassay. Carbamazepine levels in serum and saliva were highly correlated in within-patient and between-patient series (r=0.87–0.94). Salivary levels were altered to a minor and clinically insignificant degree by stimulation of saliva flow. Mean saliva/serum ratios, calculated from drug concentrations in saliva specimens collected without and with stimulation were 0.44–0.45 and 0.41–0.43, respectively. The saliva/serum ratio was independent of the serum carbamazepine level and was not affected by concomitant drug medication. The data indicate that measuring salivary levels by enzyme immunoassay is suitable for predicting serum carbamazepine levels. Thus, measurement of carbamazepine levels in mixed saliva samples obtained by a noninvasive technique is recommended for routine monitoring of carbamazepine medication in epileptic children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443121
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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