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  • 1
    Electronic Resource
    Electronic Resource
    Pankreasbeteiligung bei Morbus Wilson? (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 969-971 
    Details
    ISSN: 1432-1440
    Keywords: Wilson's disease ; Secretin-pancreozymin-test ; Exocrine pancreatic insufficiency ; Morbus Wilson ; Sekretin-Pankreozymin-Test ; Exokrine Pankreasinsuffizienz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei fünf Patienten mit Morbus Wilson (n=2 ohne Leberzirrhose,n=3 mit Leberzirrhose ohne portale Hypertonie) fand sich ein normaler Sekretin-Pankreozymin-Test; bei einem weiteren mit Leberzirrhose, aber ohne portale Hypertonie, war das Pankreas bei der Sektion histologisch unauffällig. Bei zwei Patienten mit Leberzirrhose und portaler Hypertonie zeigte sich dagegen eine verminderte Bikarbonatsekretion (n=1) und eine eingeschränkte Amylasesekretion (n=2). Die Pankreasfunktion normalisierte sich in einem Fall parallel mit einer Normalisierung des vorher pathologisch erhöhten Pfortaderdrucks unter Penicillamin-Therapie. Es wird geschlossen, daß eine Pankreasfunktionsstörung bei Morbus Wilson mit der Entwicklung und dem Fortschreiten einer Leberzirrhose zusammenhängt und nicht Ausdruck einer primären Organmanifestation ist.
    Notes: Summary A normal exocrine pancreatic function was demonstrated by the secretin-pancreozymin-test in five patients with Wilson's disease either without (n=2) or with cirrhosis of the liver but without portal hypertension (n=3). In another patient with cirrhosis of the liver without portal hypertension the pancreas was normal at post mortem examination. In two patients with cirrhosis of the liver and portal hypertension bicarbonate (n=1) and amylase secretion (n=2) were diminished. The regression of portal hypertension under therapy with penicillamine in one of the latter cases was paralleled by the return to normal of exocrine pancreatic function. It is concluded that exocrine pancreatic insufficiency in Wilson's disease is dependent on the development and the progression of chirrhosis of the liver and not due to a primary manifestation of the disease itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01480151
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  • 2
    Electronic Resource
    Electronic Resource
    Is the assay of disaccharidase activity in small bowel mucosal biopsy relevant for clinical gastroenterologists? (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 568-575 
    Details
    ISSN: 1432-1440
    Keywords: Disaccharidases ; Small bowel biopsy ; Celiac sprue ; Lactase deficiency ; Chronic pancreatitis ; Giardiasis ; Crohn's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a retrospective study, jejunal mucosal disaccharidase and alkaline phosphatase activities have been investigated in 40 controls and patients with proven celiac sprue (n=26), lactase deficiency (n=26), osteoporosis or osteomalacia (n=16), chronic pancreatitis (n=12), giardiasis (n=7), or Crohn's disease (n=7). Apart from a nonselective reduction of mucosal enzyme activities in the sprue syndrome and a selective reduction of lactase activity in the patients with primary lactase deficiency, assays of mucosal disaccharidases revealed only inconstant or slight deviations from the control group and were not of diagnostic significance for any of the above-mentioned disorders. Isolated forms of enzyme deficiencies other than lactase deficiency, such as sucrase-isomaltase or trehalase deficiency were not present among 168 investigations carried out from 1972–1982. It is concluded that assay of small intestinal disaccharidase or alkaline phosphatase activities does not expand the diagnostic impact of morphological examination of small bowel biopsy specimens and modern noninvasive methods for the detection of carbohydrate malabsorption. Thus, the method does not appear a necessary or relevant investigation in routine clinical practice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721683
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  • 3
    Electronic Resource
    Electronic Resource
    Salivary electrolytes in digitalis-treated patients with and without raised aldosterone excretion (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 1174-1176 
    Details
    ISSN: 1432-1440
    Keywords: salivary electrolytes ; digoxin concentration ; aldosterone ; spironolactone ; Speichelelektrolyte ; Digoxinkonzentration ; Aldosteron ; Spironolactone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Speichelelektrolyte (Natrium, Kalium, Calcium) wurden bei 10 mit Herzglykosiden und Spironolactone behandelten Patienten bestimmt. Bei zwei Patienten lag eine Digitalisintoxikation vor. Zwischen Speichelelektrolyten und Serumdigoxinkonzentration wurde, sowohl bei erhöhter als auch bei nicht erhöhter Aldosteronausscheidung im Urin eine gute Korrelation festgestellt. Aufgrund unserer Befunde ist zu vermuten, daß die durch Herzglykosidbehandlung hervorgerufenen Speichelelektrolytveränderungen unabhängig sind von einem gleichzeitig bestehenden sekundären Aldosteronismus und einer Spironolactonetherapie.
    Notes: Summary Salivary electrolytes (sodium, potassium, calcium) were measured in 10 digitalis-treated patients receiving spironolactone. Two of them could be identified as digitalis-intoxicated. The results showed good correlation with digoxin concentration in serum irrespective of whether aldosterone excretion was increased or not. This leads to the suggestion that the salivary electrolyte changes effected by digitalis treatment are independent from secondary aldosteronism and spironolactone therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468569
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  • 4
    Electronic Resource
    Electronic Resource
    Peritoneal dialysis in small laboratory animals (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 743-745 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Healthy rats and guinea-pigs were treated with a simple method of continuous peritoneal dialysis for 12, 24 and 48 h. Increasing with time, both animal species developed severe hypoproteinemia and hemoconcentration due to protein loss into the dialyzate fluid. These changes were associated with a high mortality rate, when Sterofundin® was used for dialysis. Therefore, protein loss should be substituted and the type of dialyzate must be considered in experimental long-term dialysis using these small laboratory animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01944165
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  • 5
    Electronic Resource
    Electronic Resource
    Potentiation of haemolysis by the combined action of phospholipase A and a basic peptide containing S-S-bonds (Viscotoxin B) (1971)
    Springer
    Cellular and molecular life sciences 27 (1971), S. 122-123 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Viscotoxin B, ein basisches Peptid mit Disulfidgruppen, zeigt in der Hämolyse den gleichen synergistischen Effekt mit Phospholipase A wie der direkt lytische Faktor des Kobragiftes. Dieses Ergebnis stützt die Hypothese, dass Zellmembranen durch Reaktionen ihrer Protein-SH-Gruppen so verändert werden können, dass Phospholipase A sonst unzugängliche Membranphospholipide angreift.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02145845
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  • 6
    Electronic Resource
    Electronic Resource
    Complement system in sodium taurocholate pancreatitis in the rat (1978)
    Springer
    Research in experimental medicine 174 (1978), S. 57-65 
    Details
    ISSN: 1433-8580
    Keywords: Complement system ; Sodium taurocholate ; Acute experimental pancreatitis ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of the complement system was studied in Na-taurocholate pancreatitis in rats. Complement activity (CH 50) was determined at various times in the course of pancreatitis. Immediately after induction of acute pancreatitis, serum complement activity declined and massive C 3 deposits could be detected in the vicinity of acinar necroses and necrobioses. After a phase of recovery three to six hours postoperatively a second complement consumption occurred. Lethality rate increased as serum complement activity fell below 50% of preoperative values. The degree of C 3 deposition increased up to six hours. Decline of serum complement activity and deposition within the pancreas seemed to be correlated with histologically demonstrable tissue lesion. The first decline of complement activity in serum is thought to be caused by liberation of complement activating substances within the pancreas due to the detergent action of Na-taurocholate itself. The second decline, however, may be due to the liberation of complement activating and/or destroying enzymes into the blood stream.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851939
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  • 7
    Electronic Resource
    Electronic Resource
    Influence of buprenorphine on acute experimental pancreatitis (1987)
    Springer
    Research in experimental medicine 187 (1987), S. 211-216 
    Details
    ISSN: 1433-8580
    Keywords: Acute experimental pancreatitis ; Pain ; Enzymes ; Buprenorphine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Buprenorphine (15 µg/kg b.wt. per hour) distinctly reduced pain sensitivity in acute 3% sodium-taurocholate pancreatitis in male Wistar rats without interfering with the course of the disease. This was seen by assessment of enzyme elevation in serum and ascites and by histological evaluation of the pancreas. Buprenorphine is therefore recommended for animal experiments to study the effect of therapeutic principles in acute pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852085
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  • 8
    Electronic Resource
    Electronic Resource
    Correlation of pancreatic enzyme levels with the patient's recovery from acute edematous pancreatitis (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 565-569 
    Details
    ISSN: 1432-1440
    Keywords: Acute pancreatitis ; Amylase ; Clinical course ; Immunoreactive trypsin ; Lipase ; Pancreatic isoamylase ; Serum enzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Levels of total amylase, pancreatic isoamylase, lipase and immunoreactive trypsin were measured in 27 consecutive patients with noncomplicated (methemalbumin negative, no pseudocysts on ultrasound) acute pancreatitis during the acute, subacute, and recovery phases. At the beginning of the recovery phase (no pain, start of oral food intake), amylase and pancreatic isoamylase were below normal, whereas lipase (12% of the patients) and especially trypsin (52% of the patients) were still three times above the upper limit of normal. None of the patients showed a relapse of pain at the time of oral food intake. The conclusion is that amylase and pancreatic isoamylase reflect more accurately the patient's recovery pattern in acute pancreatitis than the other enzymes. Trypsin, however, may be significant in cases of delayed diagnosis. Thus, the decision to start oral food intake should be based on the patient's clinical state rather than on pancreatic enzyme levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01667149
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  • 9
    Electronic Resource
    Electronic Resource
    Changes in Na+ and K+ permeability of red cells induced by the direct lytic factor of cobra venom and phospholipase A (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 274 (1972), S. 81-90 
    Details
    ISSN: 1432-1912
    Keywords: Direct Lytic Factor ; Phospholipase A ; Red Cells ; Ion Permeability ; Haemolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of the direct lytic factor (DLF) of cobra venom, bee venom phospholipase A and of combinations of these two lysins on guinea-pig red cells have been studied. DLF caused an increased permeability to Na ions, swelling of the cells and moderate haemolysis. No prelytic loss of potassium was seen. Phospholipase A produced loss of potassium, considerable gain of sodium, cell swelling, but no remarkable lysis. Combinations of the two venom constituents, more strongly haemolytic, mimicked the effect of the predominant component of the mixture. Thus prelytic loss of potassium was observed when higher concentrations of phospholipase were combined with low concentrations of DLF, but was absent when DLF predominated. The rather low critical volume and spherocytosis of haemolysing red cells exposed to DLF, and the effect of DLF on osmotic stability suggest that DLF has other effects on the cell membrane in addition to those of an osmotic haemolysin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501009
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  • 10
    Electronic Resource
    Electronic Resource
    Possible implication of glutathione reductase in haemolysis by the direct lytic factor of cobra venom (Naja naja) (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 275 (1972), S. 203-211 
    Details
    ISSN: 1432-1912
    Keywords: Glutathione Reductase ; Glutathione ; Haemolysis ; Direct Lytic Factor ; Disulphides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The activity of glutathione reductase (GR) was measured in haemolysates and red cell membranes of various species. The enzyme levels were compared with the susceptibility of the respective cells to the direct lytic factor (DLF) of cobra venom. A positive correlation was found in so far as cells having high (low) GR activity were highly (little) sensitive to DLF. Further results make it likely that GR is implicated in DLF-induced lysis: 1. By enzymatic assay an interaction of membrane bound GR and DLF was found, as evident from consumption of the coenzyme NADPH. 2. Glutathione in the reduced state (GSH) as well as in the oxidized form (GSSG) inhibited haemolysis by DLF in a dose-dependent manner. A chemical interaction between DLF and glutathione was excluded. 3. NADPH showed a dual effect: it accelerated DLF-induced haemolysis at low concentrations, whereas at high concentrations inhibition was evident.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508908
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