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  • 1
    Electronic Resource
    Electronic Resource
    Familiäre Dialbuminämie vom langsam wandernden Typ (1968)
    Springer
    Journal of molecular medicine 46 (1968), S. 555-556 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Two families with dominant inherited bisalbuminemia of the slow moving type were examined. The electrophoretic pattern of the paralbumin displayed diminished migratory behaviour with respect to the normal serumalbuminfraction. The pure extract of liver cell albumin of one heriditarily afflicted member showed two different albuminfractions too.
    Notes: Zusammenfassung Zwei Familien mit dominant erblicher Dialbuminämie vom langsam wandernden Typ wurden untersucht. Das Elektrophoresebild zeigte eine verminderte Wanderungsgeschwindigkeit des abartigen Albumins gegenüber der normalen Serumalbuminfraktion. Bei einem Erbmalsträger konnte die Verdoppelung der Albuminfraktionen im rein dargestellten Leberzelleiweiß nachgewiesen werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01747776
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  • 2
    Electronic Resource
    Electronic Resource
    Deposition of polymeric IgA1 in idiopathic mesangial IgA-glomerulonephritis (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 911-915 
    Details
    ISSN: 1432-1440
    Keywords: Mesangial IgA-glomerulonephritis ; IgA1 ; Polymeric IgA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary IgA deposits in kidney and skin biopsies from patients with idiopathic mesangial IgA-glomerulonephritis were characterized with immunofluorescence microscopy using monoclonal antibodies against the IgA subclasses IgA1 and IgA2. IgA1 was the major constituent in all biopsy specimens. Double immunofluorescence microscopy showed that IgA deposits were constantly associated with J-chain. Secretory component was never found in the deposited material. In vitro fixation of free secretory component, however, was observed in some biopsies. These findings indicate that most if not all of the deposited IgA in patients with idiopathic IgA-glomerulonephritis is polymeric in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01537531
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  • 3
    Electronic Resource
    Electronic Resource
    Inaktivierung von Pentagastrin (ICI 50, 123) durch Humanserum und Leberhomogenat (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 1069-1070 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The stimulating activity of Pentagastrin (ICI 50, 123) on gastric secretion of HCl was investigated. After incubation with human serum and homogenate of rat liver Pentagastrin lost its stimulating activity in rat stomach depending on time of incubation and on serum volume. We conclude, that an enzymatic hydrolysis of Pentagastrin took place.
    Notes: Zusammenfassung Die säurestimulierende Wirkung von Pentagastrin (ICI 50, 123) nach Inkubation mit Humanserum und Leberhomogenat wurde am Rattenmagen untersucht. Wir fanden eine von der Inkubationsdauer und von der Menge des Inkubationsgemisches abhängige Senkung der Pentagastrinaktivität, was auf eine enzymatische Hydrolyse schließen läßt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01497216
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  • 4
    Electronic Resource
    Electronic Resource
    Immunhistologische Untersuchungen bei der diffusen mesangialen Sklerose mit nephrotischem Syndrom im Säuglingsalter (1975)
    Springer
    European journal of pediatrics 120 (1975), S. 111-120 
    Details
    ISSN: 1432-1076
    Keywords: Infantile nephrotic syndrome ; Mesangial sclerosis ; Immunohistology ; Pathogenesis of nephrotic syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einem Säugling, der im Alter von 10 Monaten an einem steroid-resistenten nephrotischen Syndrom erkrankte, wurde bei der Nierenbiopsie eine diffuse mesangiale Sklerose der Glomeruli festgestellt. Nach dem Tod an interstitieller Pneumonie 3 Monate nach Krankheitsbeginn wurde der Nierenbefund bestätigt. Der Prozeß betraf sämtliche Glomeruli, war aber segmental verschieden stark ausgeprägt. Immunhistologisch wurden granuläre Ablagerungen von IgM und Komplement (C3) im Mesangium und subendothelial an der Basalmembran beobachtet. Die Befunde sprechen dafür, daß bei der Pathogenese der diffusen mesangialen Sklerose möglicherweise die Bildung und glomeruläre Ablagerung von Immunkomplexen eine Rolle spielen.
    Notes: Abstract A 10-month-old infant developed a steroid resistant nephrotic syndrome. The renal biopsy revealed diffuse mesangial sclerosis of the glomerula. The child died from interstitial pneumonia 3 months after onset of the renal symptoms. Post mortem, the glomerular changes were diffuse but prominent in certain segments of the glomeruli. The immunohistological examination showed granular deposits of IgM and C3 in the mesangium and in the subendothelial region of the basement membrane. These findings are compatible with the hypo. thesis that diffuse mesangial sclerosis is caused by glomerular deposition of immune complexes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445160
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  • 5
    Electronic Resource
    Electronic Resource
    Idiopathic mesangial IgA-glomerulonephritis in childhood (1980)
    Springer
    European journal of pediatrics 134 (1980), S. 13-22 
    Details
    ISSN: 1432-1076
    Keywords: IgA-Glomerulonephritis ; Haematuria ; Proteinuria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nineteen out of 83 children with asymptomatic haematuria were classified as having IgA glomerulonephritis, characterized by diffuse mesangial deposition of IgA in the absence of systematic disease. Different histological patterns were observed: i.e., minor glomerular lesions (5 cases), focal and segmental proliferative glomerulonephritis (8 cases) and diffuse proliferative glomerulonephritis (6 cases). Recurrent gross haematuria is the clinical hallmark of the disease. Proteinuria was present in 14 children and exceeded 1 g/m2/day in 3 patients. Clinico-pathological correlations showed a close relation between the degree of proteinuria and the histological lesions. Serum IgA levels were elevated in 3 children. Glomerular filtration rate remained above 80 ml/min/1.73 m2 in a 1 to 9 year follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442397
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  • 6
    Electronic Resource
    Electronic Resource
    Membranoproliferative glomerulonephritis in systemic sclerosis of childhood (1978)
    Springer
    Virchows Archiv 379 (1978), S. 169-179 
    Details
    ISSN: 1432-2307
    Keywords: Progressive systemic sclerosis in childhood ; Segmental membranoproliferative glomerulonephritis ; Immune complex disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The renal lesions of a 5-year-old girl with progressive systemic sclerosis are described. The nephropathy was clinically characterised by moderate proteinuria, microscopic hematuria and transient hypertension. Light microscopy showed membranoproliferative glomerulonephritis of segmental character. On electron microscopy intramesangial, subendothelial and extramembranous glomerular deposits were observed. By immunofluorescence microscopy deposits of IgG, Clq, C4, C3, C5, C8 und C9 in a predominantly subendothelial location were found in all glomeruli. Vascular lesions were of minor degree. Histological and immunohistological findings are compatible with an immune complex disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432486
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  • 7
    Electronic Resource
    Electronic Resource
    Complement system in sodium taurocholate pancreatitis in the rat (1978)
    Springer
    Research in experimental medicine 174 (1978), S. 57-65 
    Details
    ISSN: 1433-8580
    Keywords: Complement system ; Sodium taurocholate ; Acute experimental pancreatitis ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of the complement system was studied in Na-taurocholate pancreatitis in rats. Complement activity (CH 50) was determined at various times in the course of pancreatitis. Immediately after induction of acute pancreatitis, serum complement activity declined and massive C 3 deposits could be detected in the vicinity of acinar necroses and necrobioses. After a phase of recovery three to six hours postoperatively a second complement consumption occurred. Lethality rate increased as serum complement activity fell below 50% of preoperative values. The degree of C 3 deposition increased up to six hours. Decline of serum complement activity and deposition within the pancreas seemed to be correlated with histologically demonstrable tissue lesion. The first decline of complement activity in serum is thought to be caused by liberation of complement activating substances within the pancreas due to the detergent action of Na-taurocholate itself. The second decline, however, may be due to the liberation of complement activating and/or destroying enzymes into the blood stream.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851939
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  • 8
    Electronic Resource
    Electronic Resource
    Complement-mediated acinar cell necroses in pancreatitis induced by basement membrane antibodies (1976)
    Springer
    Virchows Archiv 371 (1976), S. 69-77 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Rolle des Serumkomplementsystems für die Entwicklung der initialen Acinuszellnekrose bei akuten Pankreatitiden wurde untersucht. Nach intraduktaler Injektion von Basalmembran-Antikörpern entwickelten sich im Verlauf von 10–30 min bei Ratten und Mäusen Azinuszellnekrosen in unmittelbarer Nachbarschaft der an den Basalmembranen darstellbaren Antikörper- und Komplementablagerungen. Das Ausmaß des Parenchymschadens und der Komplementablagerungen stand in direkter Korrelation zu der injizierten Antikörpermenge. Die Bedeutung des zytolytisch aktiven Komplements für die Entwicklung der Nekrosen wurde durch Untersuchungen an Komplement-defekten Mäusen herausgestellt. Während sich bei den genetisch C5-defekten DBA2J- und B10D2 old line-Mäusen keine Azinuszellnekrosen entwickelten, zeigten die mormokomplementämischen C57 Black- und B10D2 new line-Mäuse ausgedehnte Nekrosefelder nach intraduktaler Antikörper-applikation. Die Ergebnisse lassen vermuten, daß zytolytisch aktives Komplement für den initialen Membranschaden der Azinuszelle bei der akuten autodigestiven Pankreatitis verantwortlich ist.
    Notes: Summary To study the role of the serum complement system in the early necrosis of acinar cells an acute pancreatitis was produced by injection of basement membrane antibodies into the pancreatic duct of mice and rats. In all animals deposition of complement (C3) and antibasement membrane IgG could be observed in an identical position within areas of acinar cell necrosis. The extent of parenchymal damage and the intensity of complement deposits corresponded to the injected dose of antibodies. The importance of cytolytically active complement components (C5–9) was demonstrated in congenitally C5-defective old line mice which did not show typical centrolobular necroses 1 h after intraductal injection of antibodies. However, the normocomplementemic mice developed extensive necroses of acinar cells. These results support the hypothesis of a complement-induced acinar cell necrosis in acute pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433716
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  • 9
    Electronic Resource
    Electronic Resource
    The serum complement system — a mediator of acute pancreatitis (1975)
    Springer
    Virchows Archiv 365 (1975), S. 193-199 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of the complement system in the initial membrane lesion of acute pancreatitis was investigated. In the experimental sodium-taurocholate pancreatitis of the rat a sudden and steady decline of serum complement was observed. The deposition of 03 component of complement in acute pancreatitis could he demonstrated by immunofluorescence. To rule out mere deposition or activation of complement in the interstitial exsudative fluid, single acinar cells of rat and rabbit pancreatic tissue were prepared and transfered to culture medium. In contrast to heat inactivated serum and C6 deficient serum these cells were lysed by trypsin activated fresh serum. Consequently, an acute pancreatitis could be induced by activating exclusively the complement system by injection of cobra venom factor into the pancreatic duct of rats. The activated complement system is thought to be responsible for initial membrane lesion in exsudative inflammation, as could be shown in acute pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00434038
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  • 10
    Electronic Resource
    Electronic Resource
    Der Einfluß der Autolyse auf die immunhistologische Darstellbarkeit gewebegebundener Immunglobuline in der Niere (1975)
    Springer
    Virchows Archiv 365 (1975), S. 151-161 
    Details
    ISSN: 1432-2307
    Keywords: Autolysis ; Peroxydase-Labeled Antibodies ; Glomerular Basement Membrane ; Autofluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einfluß der Autolyse auf die immunhistologische Darstellbarkeit und die immunologischen Eigenschaften gewebegebundener Basalmembranantikörper an Rattennieren wurde untersucht. Der immunhistologische Nachweis der Antikörper war bis zu einem Zeitpunkt von 3 Tagen nach Eintritt des Todes nicht beeinträchtigt. Durch die Verwendung peroxydasemarkierter Antiseren konnte die störende Autofluorescenz des autolytischen Gewebes umgangen werden. Die nach 2tägiger Autolyse aus den Nieren eluierten Basalmembranantikörper lagerten sich nach Reinjektion wiederum in homogen-linearem Muster an der glomerulären Basalmembran ab, ihre Antikörpereigenschaften waren nicht beeinträchtigt.
    Notes: Summary The influence of autolysis on the immunhistological detectability and the immunological properties of tissue-bound basement membrane antibodies were investigated in the rat kidney. The immunhistological demonstration of antibodies was not affected up to 3 days post mortem. The disturbing autofluorescence of the autolytic tissue can be avoided by using peroxydase labeled antibodies. Basement-membrane antibodies that were eluted from the kidneys after an autolysis period of 2 days showed a homogenous linear deposition in kidney basement membrane after reinjection into normal rats. Their antibody properties were not affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432386
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