ISSN:
1432-1076
Keywords:
HIV infection
;
Immune deficiency
;
Neuro-developmental delay
;
CSF folate levels
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Three children presenting with neurological symptoms were subsequently diagnosed as being infected with the human immunodeficiency virus I (HIV). All children showed normal development for about 12–18 months of age but later developed psychomotor and developmental regression. One child presented with generalised hypotonia, another with focal seizures, and the third with spastic quadriplegia. Two of the children showed areas of abnormal brain density on computed tomography and in one case there was calcification of the basal ganglia. In two of the children cerebrospinal fluid contained reduced amounts of total folate and elevated concentrations of neopterin. The possibility of a link between the deranged folate metabolism and the neurological symptoms in HIV infections is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00444122
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