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Effects of gemcitabine on cell proliferation and apoptosis in non-small-cell lung cancer (NSCLC) cell lines (2000)

Pace, E. ; Melis, M. ; Siena, L. ; [et al.]

Springer

Cancer chemotherapy and pharmacology 46 (2000), S. 467-476

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ISSN: 1432-0843

Keywords: Key words Gemcitabine ; Non-small-cell lung cancer ; NSCLC ; Apoptosis

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract We evaluated the antiproliferative and the proapoptotic ability of gemcitabine in three non-small-cell lung cancer (NSCLC) cell lines. NCI-H292 (mucoepidermoid carcinoma), NCI-CorL23 (large-cell carcinoma) and NCI-Colo699 (adenocarcinoma) cells were cultured with and without 0.5, 0.05 and 0.005 μM gemcitabine for 24, 48 and 72 h, respectively. Gemcitabine exerted a stronger and earlier antiproliferative and proapoptotic effect on H292 cells than on CorL23 or Colo699 cells. Fas receptor expression was increased in all three cell lines and was higher in Colo699 than in CorL23 cells. The incubation of NSCLC with anti-Fas agonistic monoclonal antibody (CH11) induced cell apoptosis in H292 cells, demonstrating that the Fas receptor was functionally active. Finally, gemcitabine and CH-11 exerted a synergistic effect on cell apoptosis in H292 cells. This study demonstrates that gemcitabine induces apoptosis in NSCLC and that this effect might be exerted by modulating functionally active Fas expression, and these effects of gemcitabine were stronger in H292 cells than in either CorL23 or Colo699 cells.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002800000183

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A new class of aromatic poly-ether-aroyl-oxadiazoles. II. Studies on the cyclization reaction, infrared, structural, and morphological characterization (1994)

Calandrelli, L. ; Di Pace, E. ; Laurienzo, P. ; [et al.]

Bognor Regis [u.a.] : Wiley-Blackwell

Journal of Polymer Science Part B: Polymer Physics 32 (1994), S. 1249-1256

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ISSN: 0887-6266

Keywords: polyoxadiazoles ; IR ; structure ; morphology ; Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Notes: Poly-ether-aroyl-oxadiazoles (PEODZ) of general formula: are reported.Thermal cyclization of the starting polyhydrazides, infrared, thermal, and structural characterization are discussed as function of the number of methylene spacers in the range 2-12.It is found that the position of melting is strongly dependent upon the number of—CH2—, and that moldable polyoxadiazoles are obtained at × values 〉 7. The spherulitic nature of PEODZ is clearly revealed by thermal-optical microscopy which, together with isothermal crystallizations at the differential scanning calorimeter, gives a close insight into the crystalline organization of such polymers. © 1994 John Wiley & Sons, Inc.

Additional Material: 9 Ill.