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  • 1
    Electronic Resource
    Electronic Resource
    Einflu\ von Absto\ungskrisen und immunsuppressiver Therapie auf die Lymphozytensubpopulationen von Patienten nach Nierentransplantation (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 408-414 
    Details
    ISSN: 1432-1440
    Keywords: Renal transplantation ; Immunosuppression ; Cyclosporine A ; Immunologic monitoring ; T lymphocytes ; Cell surface antigens ; Monoclonal antibodies ; Flow cytometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The lymphocyte subsets in the peripheral blood were examined 3 times a week in 17 patients receiving a cadaveric renal allograft using 2-color flow cytometry and several combinations of monoclonal antibodies. Patients who experienced a rejection crisis (n=12) had a significantly higher CD4/CD8-ratio (2.72±1.26 mean±SD) than patients with stable graft function (1.76±1.33, p〈0.05). 9/12 patients showed 0–3 days prior to the rejection episode an increase of the CD4/CD8-ratio (≥0.5) and/or a high ratio (≥2.5) with a decrease following antirejection therapy. The activation markers HLA-DR and IL-2 receptor on T cells were increased only during 3/12 rejection episodes. Patients with rejections resistant to prednisone pulse therapy (n=6) had significantly more lymphocytes/mm3 in the peripheral blood (1111.7±597.5) than successfully treated patients (n=6, 336.7±196.0, p〈0.02). Antirejection therapy with prednisone pulses and/or antithymocyte globuline resulted in a significant decrease of T lymphocytes (CD3+) with a selective reduction of T helper/inducer cells (CD4+). 6 months after renal transplantation the patients had a higher percentage of suppressor/cytotoxic cells (CD8+) compared to the pretransplant values (26.3±10.9% vs 17.7±6.2%, p〈0.02) and blood donors (16.3±6.2%, p〈0.01). Furthermore the percentage of T helper cells (CD4+/CD28−) was significantly higher and the T suppressor-inducer cells (CD4+/CD28+) were significantly lower compared to the controls. Serial flow cytometric determinations of lymphocyte subsets in renal allograft recipients may be helpful in some cases although rejection episodes could not be predicted in the individual patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01648582
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  • 2
    Electronic Resource
    Electronic Resource
    Akute Leukämie nach Nierentransplantation (1980)
    Springer
    Annals of hematology 40 (1980), S. 343-348 
    Details
    ISSN: 1432-0584
    Keywords: Acute leukemia ; Immunosuppressive therapy ; Kidney allotransplantation ; Akute Leukämie ; Immunosuppression ; Nierenallotransplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der Literatur sind vier Fälle mit Entwicklung einer akuten myeloischen und sechs Fälle mit Entwicklung einer chronischen myeloischen Leukämie unter Immunosuppression mit Azathioprin und Prednison bei nierentransplantierten Patienten beschrieben. Wir berichten über zwei weitere akute Leukämien während chronischer Immunosuppression bei Zustand nach Nierentransplantation. Der erste, 29jährige Patient entwickelte zehn Jahre nach erfolgreicher Nierentransplantation die Zeichen einer akuten lymphatischen Leukämie. Beim zweiten, 47jährigen Patienten wurden fünf Jahre nach erfolgreicher Nierentransplantation Hepatosplenomegalie und Pancytopenie beobachtet; nach Splenektomie wurde die Diagnose einer subakuten myeloischen Leukämie gestellt. Beide Patienten standen unter langdauernder immunosuppressiver Therapie (Azathioprin und Prednison),die in beiden Fällen nach der Diagnose einer Leukämie abgesetzt wurde. Ein Zusammenhang zwischen dem Auftreten der Leukämie und der chronischen Immunosuppression wird postuliert.
    Notes: Summary Four cases of acute myelogenous leukemia and six cases of chronic myelogenous leukemia after treatment with azathioprine and prednisone for renal allotransplantation have been described in the literature. We report another two cases of acute leukemia 10 and 5 years after successful renal allotransplantation. Patient 1, a 29-year-old farmer, exhibited the signs of acute lymphatic leukemia resistent to treatment with cytostatic agents. Death was due to pneumonia. Patient 2, a 47-year-old salesman, developed pancytopenia together with splenomegaly. After splenectomy an atypical subacute myeloid leukemia became apparent which was not treated due to withdrawal of the patient. He died 2 months after diagnosis. Both patients received long-term immunosuppressive therapy with azathiopine and prednisone until the leukemia was diagnosed. A relationship between long-term immunosuppression and the occurrence of leukemia is postulated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01025589
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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