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  • Chemistry  (39)
  • Chemotherapy  (2)
  • Kartoffelaroma  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Journal of molecular medicine 65 (1987), S. 338-340 
    ISSN: 1432-1440
    Schlagwort(e): Porphyria ; Chemotherapy ; Acute myelogenous leukemia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The safety of drugs in hepatic porphyrias has largely been established by clinical experience, which is very limited in the case of antineoplastic agents. We administered three cycles of polychemotherapy consisting of daunorubicin, cytarabine and 6-thioguanine, and modified supportive care to a 33-year-old Turkish woman suffering from acute myelogenous leukemia. The urinary excretion of total porphyrins, porphobilinogen, and aminolevulinic acid was continuously monitored. Excreation of these metabolites was permanently elevated, but the values were comparatively low during cytotoxic therapy while peak values were recorded at the onset of fever during bone marrow aplasia; yet there were no clinical signs of porphyritic attacks at that time. A few potentially unsafe drugs were tolerated without an increase in porphyrin excretion. Although the susceptibility to drugs is highly variable in patients with hepatic porphyrias, the treatment of malignancy in these patients seems justified as long as porphyrin excretion under therapy is not grossly elevated over baseline values and appropriately modified supportive care is administered.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. S203 
    ISSN: 1432-1335
    Schlagwort(e): rhGM-CSF ; Small-cell lung cancer ; Chemotherapy ; Haemopoietic recovery
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In three consecutive pilot studies the effect of recombinant human granulocyte/macrophage-colony-stimulating factor (rhGM-CSF) on haematopoetic recovery after chemotherapy in patients with small-cell lung cancer was investigated. In study I, 20 patients received AIO chemotherapy (A, Adriamycin 25 mg/m2 on days 1+2; I, ifosfamide 2 g/m2 on days 1–5; O, vincristine 2 mg on day 1) at 4-week intervals either with or without rhGM-CSF (250 μg/m2 sc) from day 8 until recovery of leucocytes. Neither the degree nor the duration of myelosuppression was markedly influenced by rhGM-CSF. Suggesting that these disappointing results were caused by the late onset of GM-CSF application, in the following study we shortened chemotherapy to 3 days and started with GM-CSF on day 4. The main objective of this study was to test whether the earlier administration of GM-CSF allowed treatment intervals to be reduced or the dose to be escalated. After 10 patients had received a starting dose of AIO (A, 50 mg/m2 on day 1; I, 2 g/m2 on days 1–3; 0,2 mg on day 1) alternating with cisplatin (90 mg/m2 on day 1) and etoposide (150 mg/m2 on days 1–3), the dose of ifosfamide and etoposide was escalated to 2.5 g/m2 on days 1–3 and 200 mg/m2 on days 1–3 in the next 10 patients. Treatment was given at 2-week intervals when leucocytes were 〉 3500/mm3 and thrombocytes were 〉 100 000 mm3 on day 14. At each dose level patients were randomized to receive either rhGM-CSF 250 μg/m2 s.c. on days 4–12 or no GM-CSF. In this study, rhGM-CSF markedly shortened the duration of leukopenia. Reinstitution of chemotherapy on day 15 was possible at dose level 1 in 1/4 patients without and in 3/4 patients with GM-CSF, and at dose level 2 in 0/5 patients without and in 5/5 patients with GM-CSF. However, the degree of myelosuppression was not improved by GMCSF. In a third study we tried to apply rhGM-CSF simultaneously with chemotherapy. After 3 patients had received GM-CSF starting on day 1 concurrent to AIO chemotherapy, we noticed an increase of myelosuppression with prolonged neutropenia and thrombocytopenia and stopped this investigation. Considering all patients included in these three consecutive pilot studies, there is no difference in response rates and survival between patients with and without rhGM-CSF treatment. Optimal scheduled rhGM-CSF application shortens the period of myelosuppression and allows reinstitution of chemotherapy at 2-week intervals. Whether these modifications are able to improve the overall treatment results, has to be determined in future clinical trials.
    Materialart: Digitale Medien
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  • 3
    ISSN: 0887-624X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Poly[(4-N-ethylene-N-ethylamino)-α-cyanocinnamate] was prepared by solution esterification of (4-N-ethyl-N-(2-hydroxyethyl) amino)-α-Cyanocinnamic acid and by melt transesterification of ethyl (4-N-ethyl-N-(2-hydroxyethyl) amino)-α-cyanocinnamate. The melt transesterification generally yielded polymer with a number-average molecular weight of about 10,200 by gel permeation chromatography (GPC) versus polystyrene standards. The polymer was found to be amorphous with a glass transition temperature of about 103°C by differential scanning calorimetry (DSC). The solution esterification generally gave a polymer with a number-average molecular weight of about 2200 by GPC versus polystyrene standards. This polymer was found to have a glass transition temperature varying between 60 and 90°C by DSC. The infrared (IR) spectrum of the polymer made from both methods were analyzed in detail. The 1H- and 13C-NMR spectra of the meltsynthesized ethyl cinnamate derivative polymer are consistent with the reported structure.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    ISSN: 0947-5117
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 11 (1960), S. 75-75 
    ISSN: 0947-5117
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 6
    ISSN: 0947-5117
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 5 (1991), S. 238-239 
    ISSN: 0951-4198
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Physik
    Notizen: Measurements of the translational energy loss accompanying the charge-stripping reactions M++N→M2++N+e- and M2++N→M3++N+e- have been performed for C60+, C70+ and C602+, C702+ respectively. The energy nesessary to remove the second electron from Buckminsterfullerene was determined, QminI=IE(C60+→C602+=12.25±0.5 eV.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 8
    ISSN: 1871-4528
    Schlagwort(e): Kartoffelaroma ; Düngung ; Solanum Tuberosum ; Stickstoff ; Kalium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Beschreibung / Inhaltsverzeichnis: Summary The effect of different nitrogen and potassium fertiliser regimes on the composition of the aroma of native potato was studied over two years in pot experiments. Analysis was done on test material with various amounts of organically fixed nitrogen and potassium (Table 1). There were clear quantitative differences in the aromatic spectrum over a wide range of nitrogen and potassium inputs. Individual components altered within the spectrum especially after high nitrogen inputs. Statistical analysis showed that only a few components could be compared in the experimental structure (Table 2), namely n-pentanol, n-hexanol, (E)-2-hexenal, n-heptanal and isomers of 2,4-decadienal (Figures 2, 3 and 4). It can be postulated that changes in the aroma of potato after increased fertiliser inputs are due to saturated and unsaturated aldehydes with their low sensory threshold values and their odour qualities. Quantitative changes of aromatics are discussed in relation to their precursors, unsaturated fatty acids from the lipid fraction of the tubers. How such changes in the raw material are reflected in potato products will require further experimentation.
    Notizen: Zusammenfassung Unter dem Einfluss differenzierter Stickstoff- und Kaligaben reagieren einzelne Aromastoffe der Kartoffel mit einem Konzentrationsanstieg. Es handelt sich dabei um die Komponenten n-Pentanol, n-Hexanol, n-Heptanal, (E)-2-Hexenal und die beiden Isomere des 2,4-Decadienals. Der Einfluss hoher und später Stickstoffgaben auf das Aromaspektrum ist deutlicher ausgeprägt, als der einer Kalidüngung. Im Hinblick auf die sensorische Qualität des Rohstoffes Kartoffel kommt dabei einzelnen Verbindungen der Charakter von ‘Leitsubstanzen’ zu.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 9
    ISSN: 1871-4528
    Schlagwort(e): Kartoffelaroma ; Solanum Tuberosum ; Tenax TA ; Kapillargaschromatographie ; Massenspektrometrie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Zusammenfassung Aromastoffe sind als wertgebende Inhaltsstoffe wesentlicher Bestandteil der Qualität pflanzlicher Lebensmittel. Sie liegen als komplexe Vielstoffgemische in unserer Nahrung vor und sind nur schwer analytisch faßbar. Den Verfahren zur Abtrennung und Anreicherung von Aromastoffen kommt daher eine besondere Bedeutung zu. Mit der ‘Dynamischen Headspace Technik’ lassen sich die flüchtigen Stoffe des nativen Kartoffelaromas unter schonenden Bedingungen isolieren. Das Aromaspektrum der rohen Kartoffel setzt sich vorwiegend aus ungesättigten Aldehyden, Alkoholen und einem Furanderivat zusammen. Für die isolierten Verbindungen lassen sich Variationskoeffizienten zwischen 3 und 20% ermitteln. Hinsichtlich des sensorischen Eindruckes zeigen die Aromakonzentrate ein typisches Kartoffelaroma.
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 61 (1978), S. 960-977 
    ISSN: 0018-019X
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: In order to investigate molecules and their interactions at interfaces we have developed a new spectroscopic technique based on integrated optics. A significant increase in sensitivity has been predicted and observed. We report here the details of the method and some preliminary spectra of organic dye molecules on thin films.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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