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  • Bone marrow transplantation  (1)
  • Key words:β-adrenoceptor agonist — Mast cells — Tryptase — TNF-α— Protein tyrosine phosphorylation  (1)
  • Krypton-81m  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The effects of S1319, a novel marine sponge-derived β2-adrenoceptor agonist, on IgE-mediated activation of human cultured mast cells (2000)
    Springer
    Inflammation research 49 (2000), S. 86-94 
    Details
    ISSN: 1420-908X
    Keywords: Key words:β-adrenoceptor agonist — Mast cells — Tryptase — TNF-α— Protein tyrosine phosphorylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: This study aimed to evaluate the abil-ity of S1319 (4-hydroxy-7-[1-(1-hydroxy-2-methylamino) ethyl]-1,3-benzothiazol-2(3H)-one acetate), a novel β 2-adrenoceptor selective agonist derived from marine sponge, to inhibit IgE-mediated activation of human cultured mast cells (HCMC) in vitro.¶Materials and Methods: We examined the effect of S1319 (racemate) on tryptase release and tumor necrosis factor- α (TNF-α) production in HCMC generated from human cord blood cells, after cross-linking of high affinity immunoglobulin E receptors (FcεRI), compared with those of the non-selective β-adrenoceptor agonist, isoproterenol (R-isomer), the selective β 2-adrenoceptor agonist, salbutamol (racemate), and the selective and long-acting β 2-adrenoceptor agonist, formoterol (racemate). We also evaluated the effect of S1319 on the intracellular cAMP level, inositol phosphate production and protein tyrosine phosphorylation in HCMC.¶Results: S1319 and β-adrenoceptor agonists inhibited the IgE-mediated release of tryptase. Approximate IC50 values of S1319, formoterol, isoproterenol and albuterol for the inhibition of tryptase release were 0.51 ± 0.12, 0.15 ± 0.1, 0.80 ± 0.09, and 28 ± 32.4 nM, respectively. S1319 and β-adrenoceptor agonists also inhibited TNF-α production by HCMC in a concentration-dependent manner. Approximate IC50 values of S1319, formoterol and isoproterenol for the inhibition of TNF-α production were 0.19 ± 0.03, 0.28 ± 0.02 and 0.32 ± 0.03 nM, respectively. S1319 caused a concentration-dependent increase in total cell cyclic AMP levels in HCMC. On the other hand, S1319 inhibited the accumulation of inositol 1,4,5-triphosphate and IgE-mediated protein tyrosine phosphorylation of 42-kDa protein, p42 mitogen activated protein (MAP) kinase (ERK-2).¶Conclusion: These results indicate that S1319 and β-adrenoceptor agonists are potent inhibitors of the IgE-mediated release of mediators from HCMC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050563
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Successful second allogeneic bone marrow transplantation in a relapsed acute myeloid leukemia patient with fungal liver abscess (1992)
    Springer
    Annals of hematology 65 (1992), S. 193-195 
    Details
    ISSN: 1432-0584
    Keywords: Bone marrow transplantation ; Fungal infection ; rhG-CSF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Disseminated fungal infection not infrequently complicates the course of allogeneic bone marrow transplantation (allo BMT) in severely immunocompromised patients, and the prognosis of BMT patients who develop systemic fungal infection is very poor. We describe a patient who developed disseminatedCandida albicans infection with liver abscess after the first allo BMT for acute myelogenous leukemia (FAB M2). The infection was successfully eradicated by the administration of miconazole and amphotericin B. However, 1 year after the first allo BMT, the patient suffered a relapse of acute myelogenous leukemia with fungal liver abscess. A second allo BMT, accelerating granulocyte recovery by recombinant human granulocyte colony-stimulating factor (rhG-CSF), was successfully performed and the fungal liver abscess resolved with a combination therapy of fluconazole and amphotericin B. The patient is alive and free of both leukemia and fungal disease more than 37 months after the first allo BMT and 25 months after the second allo BMT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01703114
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Krypton-81m single photon emission tomography and the collateral circulation in carotid occlusion: the role of the circle of Willis and leptomeningeal anastomosis (1983)
    Springer
    Journal of neurology 230 (1983), S. 7-17 
    Details
    ISSN: 1432-1459
    Keywords: Carotid artery occlusion ; Collateral circulation ; Krypton-81m ; Emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zerebrale Perfusionsbilder wurden bei Patienten mit Halsschlagaderverschluß untersucht. Dazu wurde eine Infusion mit Krypton 81m in die A. carotis comm., A. carotis int. und in die A. vertebralis vorgenommen und dann computergesteuerte Einzelphotonenemissionstomogramme angefertigt. Analysiert wurde, welchen Beitrag der Gefäßkranz an der Hirnbasis und die Anastomosen der Großhirnrinde leisten, um eine angemessene Blutversorgung des betroffenen Gebietes aufrechtzuerhalten. Man kam zu dem Schluß, daß das zerebrale Perfusionsbild in der Abschätzung von Nebenkreisläufen der Angiographie überlegen ist. Im Fall eines Halsschlagaderverschlusses ist der Gefäßkranz an der Hirnbasis von Bedeutung, einen Infarkt im Gebiet der perforierenden Arterien zu verhüten, während die Großhirnrinde vorwiegend über die Anastomosen der weichen Hirnhaut mit Blut versorgt wird, was die Hauptrolle der Anastomosen der weichen Hirnhaut beweist.
    Notes: Summary Cerebral perfusion images were investigated in patients with carotid artery occlusion, using single photon emission computed tomography with the infusion of krypton-81m into the internal, common carotid and vertebral arteries. The contribution of the circle of Willis and cerebral cortical anastomoses to the maintenance of adequate blood supply into the involved hemisphere was analysed. It was concluded that the cerebral perfusion image is superior to angiography in evaluating collateral circulation, and in the case of carotid occlusion, the circle of Willis is important in preventing infarction in the territory of the perforating arteries, while the cerebral cortex mainly receives its blood supply through the cortical leptomeningeal anastomoses, illustrating the major role of the leptomeningeal anastomosis as a collateral channel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313592
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    Paper (German National Licenses)
    Fulltext
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