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  • 1
    ISSN: 1432-1335
    Keywords: Autochthonous colonic tumors ; N-nitrosoacetoxymethyl-methylamine ; 1,2-Dimethylhydrazine ; 5-Fluorouracil ; Ftorafur ; CGP 6809 ; CGP 15'720A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Colonic tumors were induced in male Sprague-Dawley rats by ten applications of 2 mg/kg/week N-nitrosoacetoxymethyl-methylamine (AMMN) or by three applications of 100 mg/kg/month 1,2-dimethylhydrazine (1,2-DMH). Application of AMMN and 1,2-DMH induced selective colonic tumors in 97% and 29–42% of the initial animals, respectively. Colonic-tumor-bearing animals were subjected to monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A. No cures were achieved. The different therapies did not exert any clear influence on the survival time of animals, except for animals pretreated with AMMN and then subjected to ftorafur therapy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 804-804 
    ISSN: 1435-2451
    Keywords: Traumatic hemobilia ; Trauma of the liver ; Upper gastrointestinal bleeding ; Traumatische Hämobilie ; Leberverletzung ; Obere G.I.—Blutung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Symptome einer Hämobilie sind in der Trias von Sandblom zusammengefaßt: Blutung aus dem G.I.-Trakt, Ikterus, abdominelle Schmerzen. Die Blutung nach Trauma wird durch ein Arteriogramm, evtl. durch ein CT nachgewiesen. Die Hämobilie nach Leberpunktion ist schwach und zeigt sich durch einen cholestatischen Ikterus. Die Diagnostik erfolgt über eine Cholangiografie (retrograd transpapillär oder percutan transhepatisch). Die Behandlung der Blutung erfolgt durch arterielle Embolisation oder arterielle Ligatur (interparenchymatös, Lobärarterie, A. hepatica propria). Bei Verschluß-Ikterus wird endoskopisch canaliculär desobliteriert. Die Hämobilie nach Drainage schwindet meist nach Entfernung des T-Drains.
    Notes: Summary Hemobilia presents with the triad of biliary colic, obstructive jaundice and occult or gross intestinal bleeding. Bleeding after trauma is diagnosed by arteriography. Hemobilia following liver biopsy is manifested by obstructive jaundice and is diagnosed by transhepatic or retrograde endoscopic cholangiography. The bleeding should be treated by transarterial embolization, direct ligation of the bleeding point in the liver, or proximal ligation of an upstream branch of the hepatic artery. Obstructive jaundice is treated by retrograde removal of the canalicular obstruction. Hemobilia following T tube implantation vanishes in most cases after removal of the tube. Liver resection is required only in rare cases. Of our nine patients seven were saved by this regimen. Two died postoperatively, due to the extent of the liver trauma and associated injury to other organs.
    Type of Medium: Electronic Resource
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