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Digitale Medien

Attempts to suppress experimental allergic neuritis in the rat by pretreatment with antigen (1984)

Brosnan, J. V. ; Craggs, R. I. ; King, R. H. M. ; [weitere]

Springer

Acta neuropathologica 64 (1984), S. 153-160

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Details

ISSN: 1432-0533

Schlagwort(e): Experimental allergic neuritis ; Suppression ; Bovine dorsal root ; Lewis rat ; Resistance to reinduction

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The injection of bovine dorsal root antigen in complete Freund's adjuvant can be used to produce experimental allergic neuritis (EAN) in rats. In this study attempts were made to prevent the development of the disease by prior injections of antigen. It was found that eight intradermal (i.d.) injections of antigen in either incomplete Freund's adjuvant or in saline failed to suppress EAN. A single intraperitoneal (i.p.) injection of antigen in saline produced only minimal protection against the disease. However, it was found that rats which had been given a primary course of EAN were subsequently completely unresponsive to a second injection of antigen.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00695579

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