ISSN:
1432-0533
Keywords:
Experimental allergic neuritis
;
Suppression
;
Bovine dorsal root
;
Lewis rat
;
Resistance to reinduction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The injection of bovine dorsal root antigen in complete Freund's adjuvant can be used to produce experimental allergic neuritis (EAN) in rats. In this study attempts were made to prevent the development of the disease by prior injections of antigen. It was found that eight intradermal (i.d.) injections of antigen in either incomplete Freund's adjuvant or in saline failed to suppress EAN. A single intraperitoneal (i.p.) injection of antigen in saline produced only minimal protection against the disease. However, it was found that rats which had been given a primary course of EAN were subsequently completely unresponsive to a second injection of antigen.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00695579
