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  • 1
    Electronic Resource
    Electronic Resource
    A late-appearing benzodiazepine-induced hypoactivity that is not reversed by a receptor antagonist (1986)
    Springer
    Psychopharmacology 88 (1986), S. 520-524 
    Details
    ISSN: 1432-2072
    Keywords: Benzodiazepine ; Sedation ; Locomotor activity ; Exploration ; Withdrawal ; Benzodiazepine antagonist ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The activity of rats in a holeboard test is reduced 30, 90, and 240 min after treatment with a single dose of lorazepam. The administration of a benzodiazepine antagonist (RO 15-1788) 20 min before the holeboard test (i.e., 10, 70, or 220 min after lorazepam administration) reverses the hypoactivity of animals tested 30 min after treatment with lorazepam, partially reverses the hypoactivity of animals tested 90 min after receiving lorazepam, but is without effect on the hypoactivity observed 240 min after treatment with the benzodiazepine. If, however, RO 15-1788 is given at the same time as lorazepam then it reverses the hypoactivity seen 4 h later. The results of these experiments demonstrate that a benzodiazepine can exert a behavioral effect at a time when it no longer appears to be acting at central benzodiazepine receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178518
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Behavioral effects of alpha2 adrenoceptor antagonists and their interactions with ethanol in tests of locomotion, exploration and anxiety in mice (1989)
    Springer
    Psychopharmacology 97 (1989), S. 189-193 
    Details
    ISSN: 1432-2072
    Keywords: Alpha2-adrenoceptors ; Ethanol ; Anxiety ; Exploratory behavior ; Locomotor activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The behavioral effects of two highly selective alpha2-adrenoceptor antagonists, atipamezole and idazoxan, were investigated in mice using the plusmaze test of anxiety and the holeboard test of directed exploration and locomotor activity. No anxiogenic effect, as assessed by the tendency to enter the closed as opposed to open arms of the plusmaze, was noted for either drug at any dose tested. Neither were there any significant effects on locomotor activity or directed exploration (head-dipping) in the holeboard, or total plusmaze arm entries at any dose of either drug. The co-administration of either atipamezole or idazoxan had no effect on either the anxiolytic effect of ethanol (2 g/kg) or its locomotor stimulant effect in the holeboard. Atipamezole (1.0 and 3.0 mg/kg) significantly reversed the ethanol-induced reduction in exploratory head-dipping; a similar trend was seen for idazoxan. There was also a significant potentiation of the ethanol-induced increase in the number of total arm entries made on the plusmaze caused by 1.0 mg/kg (but not 3.0 mg/kg) atipamezole and both 0.3 and 1.0 mg/kg idazoxan. The results suggest that some of the behavioral effects of ethanol can be reversed by alpha2-adrenoceptor antagonists whilst others are unchanged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442248
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Behavioral interactions of fluoxetine and other 5-hydroxytryptamine uptake inhibitors with ethanol in tests of anxiety, locomotion and exploration (1988)
    Springer
    Psychopharmacology 96 (1988), S. 528-533 
    Details
    ISSN: 1432-2072
    Keywords: Mice ; 5HT Uptake inhibitors ; Ethanol ; Locomotor activity ; Anxiety
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The 5HT uptake inhibitor fluoxetine had no effect on motor activity or directed exploration (head-dipping) in a holeboard test or in an elevated plusmaze test of anxiety. Fluoxetine (20 mg/kg) attenuated the anxiolytic effect of a 2.4 g/kg dose of ethanol in the plusmaze but failed to alter ethanol's effects on exploratory head-dipping or locomotion. This interaction did not seem directly related to fluoxetine's 5HT uptake inhibiting properties because it was not observed with other 5HT uptake inhibitors (fluvoxamine and citalopram). Desipramine, which predominantly inhibits noradrenaline uptake, also failed to show effects similar to those of fluoxetine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02180035
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Time course of ethanol's effects on locomotor activity, exploration and anxiety in mice (1988)
    Springer
    Psychopharmacology 96 (1988), S. 67-72 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol ; Locomotor activity ; Exploration ; Anxiety ; Time course ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The time course of the effects of two doses of ethanol on exploration, locomotor activity and anxiety were investigated using the holeboard and plus-maze tests. In an 8 min holeboard test the lower (1.2 g/kg) dose increased both exploration and locomotor activity 0.5 h after ethanol administration whereas the higher (2.4 g/kg) dose decreased exploration but caused an even greater increase in locomotor activity. This activity increase was also seen 1 h postadministration. In the plus-maze test both doses showed an increased number of arm-entries 0.5 h and 1 h after administration but only the 2.4 g/kg dose caused anxiolytic effects persisting for over 2 h. The results add further support to the notion that the behavioral effects of ethanol vary with dose, time of administration and the behavioral measure taken.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02431535
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    Paper (German National Licenses)
    Fulltext
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