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  • Bone conductivity  (2)
  • Lymphocyte  (2)
  • Morphometry  (2)
  • 1
    Digitale Medien
    Digitale Medien
    The mononuclear cell infiltrate compared with survival in high-grade astrocytomas (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 189-193 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Astrocytoma ; Macrophage ; Lymphocyte ; Mononuclear cells ; Survival
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Frozen samples from 92 malignant astrocytomas were stained with a panel of monoclonal antibodies directed against macrophages and lymphocytes. A follow-up to death was available on 68 cases which form the basis of this study. Large numbers of macrophages were found in all cases; T lymphocytes, mostly of the CD8 phenotype were also seen in moderate numbers in 70% of cases. CD4-positive cells were present in small numbers in 32% and B cells were seen in only 8% of cases. Analysis of the survival showed no demonstrable correlation between the numbers of macrophages or CD4 lymphocytes and survival. The survival curves for parencymal CD8 infiltration diverged after 9 months suggesting increased survival for those patients without such an infiltration but the difference failed to reach statistical significance (P=0.37). No correlation between lymphocytic cuffing and survival was seen after studying all paraffinembedded material. We conclude that there is no significant statistical correlation between survival and the various types of mononuclear cell infiltrating malignant astrocytomas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688208
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  • 2
    Digitale Medien
    Digitale Medien
    Mononuclear cell infiltrate and HLA-DR expression in low grade astrocytomas (1988)
    Springer
    Acta neuropathologica 76 (1988), S. 281-286 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Astrocyte ; Macrophage ; Lymphocyte ; Major histocompatibility complex antigens ; Cellular immunity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Frozen samples from 23 low grade (grade I and II) astrocytomas were studied by means of a panel of monoclonal antibodies to macrophages, lymphocytes (and their subsets) and HLA-DR antigens. Macrophages were present in low to moderate numbers in 38%–86% of cases, the variance in figures depending on the antibody used. T lymphocytes, the majority of CD8 phenotype, were detected in low numbers in 78% of tumours. B lymphocytes were scanty in 22% (5/22) and totally absent in the remaining cases. HLA-DR antigen was expressed by tumour cells in 35% (6/17) of cases. These findings indicate that in some low grade astrocytomas there is a mononuclear cell infiltrate with macrophages and secondarily CD8+lymphocytes playing the major role. The significance of these findings remains speculative at present.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687776
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  • 3
    Digitale Medien
    Digitale Medien
    Estrogenic modulation of met-enkephalin-induced prolactin secretion in rats (1991)
    Springer
    Anatomy and embryology 183 (1991), S. 455-459 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Prolactin ; Met-enkephalin ; Estradiol ; Immunocytochemistry ; Morphometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In order to elucidate the possible role of estrogens in the sex-dependent modulation of met-enkephalin-induced prolactin secretion, and the cellular response at adenohypophyseal level, analyses of serum prolactin levels together with a morphometric study of prolactin-immunoreactive cells were carried out following intraventricular administration of the opioid to estrogenprimed male rats. Administration of the opioid led to an increase in the serum levels of the hormone and, morphometrically, a significant increase in the cellular, cytoplasmic and nuclear areas was observed. When naloxone was administered previously, the above, mentioned changes did not appear, and the values found were similar to those observed in the animals treated only with estrogens. The results suggest that the met-enkephalin-induced prolactin secretion is modulated by the gonadal steroid environment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00186434
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  • 4
    Digitale Medien
    Digitale Medien
    Morphofunctional study of mammotropic cells following intraventricular administration of met-enkephalin (1989)
    Springer
    Anatomy and embryology 179 (1989), S. 243-250 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Hypophysis ; Mammotropic cell ; Met-enkephalin ; Morphometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary An ultrastructural and morphometric study was carried out on the adenohypophyseal mammotropic cells of rats treated intraventricularly with an acute dose (150 μg) of Met-enkephalin. In the female rats, clear features of cellular hyperactivity appeared after opioid administration. The changes affected the Golgi complex, the rough endoplasmic reticulum, the mature and immature secretory granules and the images of exocytosis. Such changes did not appear when naloxone was administered before the opioid, and naloxone induced an increase in the numerical density of lysosomal dense bodies with lipoid inclusions. In the male animals, administration of an identical dose of Metenkephalin caused only a few significant changes, similar to those observed in the controls. It is concluded that Metenkephalin administered intraventricularly causes evident modifications in the mammotropic cells of female rats whereas such changes in the male animals are not significant.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00326589
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  • 5
    Digitale Medien
    Digitale Medien
    Dielectric properties of fluid-saturated bone: a comparison between diaphysis and epiphysis (1988)
    Springer
    Medical & biological engineering & computing 26 (1988), S. 313-316 
    Details
    ISSN: 1741-0444
    Schlagwort(e): Bone conductivity ; Bone impedance ; Bone permittivity ; Diaphysis ; Epiphysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02447087
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  • 6
    Digitale Medien
    Digitale Medien
    Variation of the electric properties along the diaphysis of bovine femoral bone (1991)
    Springer
    Medical & biological engineering & computing 29 (1991), S. 441-446 
    Details
    ISSN: 1741-0444
    Schlagwort(e): Bone conductivity ; Bone impedance ; Bone permittivity ; Cortical bone ; Femoral diaphysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract A preliminary study is presented of the variability of the electric properties, in the axial, tangential and radial directions, as a function of position in the diaphysis of a femoral bovine bone. The measurements were carried out at three frequencies: 100 Hz, 10 kHz and 1 MHz. It is shown that both the conductivity and the permittivity exhibit significant variations along the diaphysis, and increase in magnitude towards the epiphyses. From this study, the variation of the electric properties cannot be clearly and directly ascribed to the longitudinal variability of the total volumetric fluid content of the bone. The results reflect the orthotropic nature of the electric properties, at any given location, and indicate a position-dependent tendency towards axis symmetry.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441667
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