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Cellular and secreted tumor plasminogen activator: The effects of NaCl (1986)

Badenoch-Jones, P. ; Ramshaw, I. A. ; Grant, A.

Springer

Cellular and molecular life sciences 42 (1986), S. 433-435

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ISSN: 1420-9071

Keywords: Plasminogen activator ; NaCl ; metastasis ; MAT 13762 cells

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Plasminogen activator, secreted by metastatic tumor cells, was strongly inhibited in buffer or tissue culture medium containing physiological concentrations of NaCl. Intact cells, however, expressed strong activity under similar conditions. Thus, if plasminogen activator is involved in invasion and metastasis, the cellular activity, acting as an ectoenzyme, may be more important than secreted enzyme under physiological conditions.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02118645

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