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Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor (2000)

Liu, Qing ; Yu, Long ; Gao, Jie ; [et al.]

Springer

Molecular biology reports 27 (2000), S. 241-246

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ISSN: 1573-4978

Keywords: cDNA cloning ; chromosome 3q25–26.2 ; gene structure ; human latexin ; Northern hybridization

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract Latexin, a carboxypeptidase A inhibitor, is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat. It is used as a molecular marker for the regional specification of the neocortex. In this study, a cDNA was isolated from a human fetal brain cDNA library. The cDNA (LXN) contains an open reading frame encoding 222 amino acids. The comparison between the deduced amino acid sequences of LXN and latexins of rat and mouse revealed high sequence identity (84.2 and 84.7%, respectively). Northern blot analysis showed that LXN was expressed as a transcript of 1.3 kb in 15 out of 16 tissues examined, except in peripheral blood leukocyte. The expression levels were high in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain. It is noteworthy that the tissue distribution of human LXN differs greatly to that of its homologue in the model animal, rat latexin. In addition, the LXN gene contains at least 6 exons and spans 5.9 kb according to the genomic sequence of the clone RP11-79M21 and the gap sequence cloned in this paper. LXN was assigned to 3q25-q26.2 according to the position of the marker SHGC-35682 found adjacent to LXN gene.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1010971219806

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Spectral Lanczos decomposition method for solving single-phase fluid flow porous media (1994)

Knizhnerman, Leonid ; Druskin, Vladimir ; Liu, Qing-Huo ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Numerical Methods for Partial Differential Equations 10 (1994), S. 569-580

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ISSN: 0749-159X

Keywords: Mathematics and Statistics ; Numerical Methods

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Mathematics

Notes: A three-dimensional well model (r - θ - z) for the simulation of single-phase fluid flow in porous media is developed. Rather than directly solving the 3-D parabolic PDE (partial differential equation) for fluid flow, the PDE is transformed to a linear operator problem that is defined as u = f(A)σ, where A is a real symmetric square matrix and σ is a vector. The linear operator problem is solved by using the spectral Lanczos decomposition method. This formulation gives continuous solutions in time. A 7-point finite difference scheme is used for the spatial discretization. The model is useful for well testing problems as well as for the simulation of the wireline formation tester tool behavior in heterogeneous reservoirs. The linear operator formulation also permits us to obtain solutions in the Laplace domain, where the wellbore storage and skin can be incorporated analytically. The infinite-conductivity (uniform pressure) wellbore condition is preserved when mixed boundary conditions, such as partial penetration, occur. The numerical solutions are compared with the analytical solutions for fully and partially penetrated wells in a homogeneous reservoir. © 1994 John Wiley & Sons, Inc.

Additional Material: 5 Ill.