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  • Dendritic spines  (1)
  • Measles virus  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Measles virus matrix protein gene expression in a subacute sclerosing panencephalitis patient brain and virus isolate demonstrated by cDNA hybridization and immunocytochemistry (1987)
    Springer
    Acta neuropathologica 75 (1987), S. 123-130 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Immunocytochemistry ; In situ hybridization ; Matrix protein ; Measles virus ; Subacute sclerosing panencephalitis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Subacute sclerosing panencephalitis (SSPE) is a rare, fatal disease of children caused by a persistent measles virus infection of the central nervous system. A defect in synthesis of measles virus matrix (M) protein may be a factor in virus persistence in the brain. This study details attempts to detect expression of M protein in the brain of an SSPE patient, in the cell-associated virus isolated from this brain, and in brains of ferrets inoculated with the isolate. In situ hybridization with a tritiated cloned cDNA probe was used to search for RNA encoding M protein. Immunostaining with monospecific antiserum and the avidin-biotin-peroxidase technique was done to locate the polypeptide. The data obtained indicate that although nucleotide sequences coding for M protein were detected in the patient and ferret brains, expression of M protein in these tissues could not be detected. In the cultured SSPE virus isolate, the results were the same until the infected cells were examined by electron microscopy and a very limited expression of M protein was revealed. This suggests either diminished synthesis and/or rapid degradation of M protein in this cell-associated virus strain.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687072
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Adult fragile X syndrome (1985)
    Springer
    Acta neuropathologica 67 (1985), S. 289-295 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Fragile X ; Synapses ; Dendritic spines ; Macro-orchidism ; Golgi stain
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Fragile X syndrome [fra (X)] is currently accepted as the second most frequent chromosomal disorder associated with developmental disability. Although next to Down syndrome in frequency, no postmortem studies of confirmed adult cases had been reported. The autopsy examination of a 62-year-old, moderately retarded man with the fra (X) syndrome confirmed the preferential involvement of cerebral and testicular structures in this disorder.Dendritic spine abnormalities of the type observed in trisomic chromosomal disorders were associated with synaptic immaturity. Severe testicular hypogonadism accompanied bilateralmacro-orchidism, normal penis, and unilateral hydrocele. Valvular, articular, and testicular interstitial compartments showed normal histochemical staining characteristics for glycoproteins and lipids.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687814
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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