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  • 1
    Digitale Medien
    Digitale Medien
    Regional changes in dopamine and serotonin activation with various intensity of physical and psychological stress in the rat brain
    Amsterdam : Elsevier
    Pharmacology, Biochemistry and Behavior 49 (1994), S. 911-920 
    Details
    ISSN: 0091-3057
    Schlagwort(e): Anxiety ; Conditioned fear stress ; Dopamine ; Footshock stress ; Freezing behavior ; Medial prefrontal cortex ; Psychological stress ; Serotonin ; Stress intensity
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/0091-3057(94)90243-7
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  • 2
    Digitale Medien
    Digitale Medien
    Competitive and noncompetitive NMDA antagonists block sensitization to methamphetamine
    Amsterdam : Elsevier
    Pharmacology, Biochemistry and Behavior 48 (1994), S. 587-591 
    Details
    ISSN: 0091-3057
    Schlagwort(e): Behavioral sensitization ; D-CPP-ene Glutamate ; MK-801 ; Methamphetamine ; N-methyl-D-aspartate ; Tolerance
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/0091-3057(94)90318-2
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  • 3
    Digitale Medien
    Digitale Medien
    Scopolamine prevents augmentation of stereotypy induced by chronic methamphetamine treatment (1995)
    Springer
    Psychopharmacology 121 (1995), S. 158-163 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Methamphetamine ; Behavioral sensitization ; Scopolamine ; Acetylcholine ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Cholinergic neurotransmission has been implicated in various forms of neural plasticity such as kindling and learning. We have previously shown that blockade of muscarinic cholinergic receptors prevents the development of locomotor sensitization to methamphetamine. The present study was conducted to examine whether scopolamine, a muscarinic cholinergic antagonist, would also block augmentation of stereotypy induced by chronic methamphetamine (MA) treatment. Rats treated with MA (2.5 mg/kg, SC) for 10 days indicated significantly enhanced stereotyped behavior when tested with MA (2.5 mg/kg) after a 7-to 8- day withdrawal. Pretreatment with scopolamine (3 mg/kg) prior to MA administration prevented the augmentation of stereotypy. Rats treated with scopolamine alone showed no difference in MA-induced stereotypy compared to those treated with saline. Scopolamine methylbromide, a derivative of scopolamine that does not easily cross the blood-brain barrier, had no effect on the augmentation of stereotypy. These results suggest that stimulation of central muscarinic cholinergic receptors plays a role in the development of sensitization to the stereotypy stimulating effect of methamphetamine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02245625
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  • 4
    Digitale Medien
    Digitale Medien
    Activity of tuberoinfundibular dopaminergic neurons and concentrations of serum prolactin in the rat following lithium administration (1988)
    Springer
    Psychopharmacology 94 (1988), S. 92-96 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Dopamine ; Prolactin ; Lithium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Maintenance of rats on a lithium-containing diet for 3–21 days resulted in a suppression of prolactin (PRL) secretion in vivo and in vitro. Lithium treatment also resulted in an increase in the activity of tuberoinfundibular dopaminergic neurons, as evidenced by an increased accumulation of dihydroxyphenylalanine (DOPA) in the median eminence after inhibition of DOPA decarboxylase and an increased concentration of dopamine in the anterior pituitary gland. The accumulation of DOPA in the neurointer-mediate lobe of the pituitary gland, the prefrontal cortex, the striatum and the nucleus accumbens was also enhanced by lithium treatment. It is concluded that lithium treatment enhances the synthesis of dopamine in many brain regions and that an increased activity of tuberoinfundibular dopaminergic neurons results in an enhanced inhibitory control of PRL secretion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00735887
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  • 5
    Digitale Medien
    Digitale Medien
    Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats (1996)
    Springer
    Psychopharmacology 123 (1996), S. 182-186 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Anxiety ; Conditioned fear stress ; Freezing behavior ; Serotonin reuptake inhibitors ; Citalopram ; Fluvoxamine ; Milnacipran
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Conditioned fear stress (CFS)-induced freezing behavior has been proposed as an animal model of anxiety. In the present study, freezing was used to determine the anxiolytic activity of selective serotonin reuptake inhibitors (SSRIs), which are reported to be clinically effective in anxiety disorders. The duration of freezing behavior was reduced by acute treatment with the SSRIs citalopram (1–10 mg/kg) and fluvoxamine (3–30 mg/kg). Acute treatment with the serotonin (5-HT)/noradrenaline (NA) mixed reuptake inhibitor milnacipran (3–30 mg/kg) also attenuated CFS-induced freezing, while acute treatment with the NA reuptake inhibitors maprotiline and ORG4428, and the dopamine (DA) reuptake inhibitor GBR12909 failed to alter CFS-induced freezing. These results indicate that facilitation of 5-HT availability in the brain produced by 5-HT reuptake inhibition reduces CFS-induced freezing behavior. CFS may be a useful model for detecting the anxiolytic potential of 5-HT reuptake inhibitors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02246175
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  • 6
    Digitale Medien
    Digitale Medien
    Competitive and noncompetitive N-methyl-D-aspartate antagonists protect dopaminergic and serotonergic neurotoxicity produced by methamphetamine in various brain regions (1993)
    Springer
    Journal of neural transmission 92 (1993), S. 97-106 
    Details
    ISSN: 1435-1463
    Schlagwort(e): Methamphetamine ; neurotoxicity ; N-methyl-D-aspartate ; dopamine ; serotonin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Protective effects of NMDA antagonists on dopaminergic and serotonergic neurotoxicity produced by methamphetamine (MA) were examined. Four injections of MA (7.5 mg/kg, s.c., at 2 h intervals) caused significant decrements (40–60% of control values) in levels of dopamine (DA) and its metabolites in the rat striatum and levels of serotonin (5-HT) and its metabolite in the medial prefrontal cortex, nucleus accumbens, striatum, anterior hypothalamus, amygdala and hippocampus. These decreases in DA, 5-HT and their metabolites were prevented by pretreatment with MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, or D-CPP-ene (SDZ EAA 494), a competitive NMDA antagonist. The results suggest that NMDA receptors play a role for MA-induced serotonergic damage in various brain regions as well as dopaminergic damage in the striatum.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01244869
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