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  • 1
    ISSN: 1432-0428
    Keywords: Intestinal lipoproteins ; Sf〉400 fraction ; Sf 20–400 fraction ; insulin resistance ; insulin suppression test ; steady-state plasma glucose ; steady-state plasma insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The primary goal of the present study was to examine the effects of improved glycaemic control associated with glipizide treatment on postprandial lipaemia in non-insulin-dependent diabetic patients. The metabolism of triglyceride-rich lipoproteins of intestinal origin was assessed by measuring the retinyl palmitate content in plasma and the Svedberg flotation index (Sf)〉400 and Sf 20–400 lipoprotein fractions. Fasting plasma glucose concentrations (14.5±0.5 vs 9.0±0.5 mmol/l), glycated haemoglobin levels (13.1±0.6 vs 9.7±0.6%), and daylong plasma glucose concentrations were all significantly lower after glipizide treatment (p〈0.001). The improvement in glycaemic control was associated with increases in insulin-mediated glucose uptake (p〈0.001) and plasma post-heparin lipoprotein and hepatic lipolytic activities (p〈0.02). Both fasting plasma triglyceride (3.09±0.51 vs 2.37±0.34 mmol/l), and postprandial triglyceride concentrations (p〈0.05–0.001) were lower following glipizide treatment, associated with a significant fall in retinyl palmitate content in all three lipoprotein fractions (p〈0.02–0.001), with the most substantial decrease seen in the Sf 20–400 fraction. These data indicate that glipizide-induced improvement in glycaemic control was associated with changes in the metabolism of triglyceride-rich lipoproteins of intestinal origin that would be anticipated to reduce risk of coronary heart disease in non-insulin-dependent diabetic patients.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 101 (2000), S. 161-180 
    ISSN: 1573-2673
    Keywords: Micromechanical modeling ; cohesive force ; fracture ; heterogeneous materials ; elasticity ; fracture modes ; failure modes ; numerical simulation ; crack propagation ; ceramic composites.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A micromechanical model that provides explicit accounts for arbitrary microstructures and arbitrary fracture patterns is developed and used. The approach uses both a constitutive law for the bulk solid constituents and a constitutive law for fracture surfaces. The model is based on a cohesive surface formulation of Xu and Needleman and represents a phenomenological characterization for atomic forces on potential crack/microcrack surfaces. This framework of analysis does not require the use of continuum fracture criteria which assume, for example, the existence of K-fields. Numerical analyses carried out concern failure in the forms of crack propagation and microcrack formation. Actual microstructures of brittle alumina/titanium diboride (Al2O3/TiB2) composites are used. The results demonstrate the effects of microstructure and material inhomogeneities on the selection of failure modes in this material system. For example, the strength of interfaces between the phases is found to significantly influence the failure characteristics. When weak interfacial strength exists, interfacial debonding and microcrack initiation and growth are the principal mode of failure. When strong interfacial strength is derived from material processing, advancement of a dominant crack and crack branching are observed.
    Type of Medium: Electronic Resource
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