Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1975-1979  (2)
  • Bunina bodies  (1)
  • Motor neuron disease  (1)
  • 1
    ISSN: 1432-0533
    Keywords: Bunina bodies ; Anterior horn cells ; Amyotrophic lateral sclerosis ; Cytoplasmic laminar bodies ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Light and electron microscopic studies were made on the anterior horn cells in a case of amyotrophic lateral sclerosis. Eosinophilic inclusions of Bunina type were observed almost selectively in the motor neurons of spinal cord, as well as of brain stem, at the light microscopic level. Fine structural study revealed the presence of two types of cytoplasmic inclusions. The first, mainly corresponding to the light microscopic inclusions, were homogeneous, electron-dense, round- or oval-shaped bodies with vesicular or tubular rims and ribosome particles, about 2–5 μ in diameter, which contained filaments or other cytoplasmic components in the clear areas within them. The second were lamellar structures (laminated cytoplasmic bodies, Morales) which appeared to be originating from endoplasmic reticulum. There was no distinct transition in these two types of inclusions and the relationship to each other is not clear. The significance of Bunina body is unknown, but some manifestation of a primary disorder, e.g., protein metabolism, rather than a secondary degenerative change in the motor neurons in amyotorophic lateral sclerosis.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 219 (1978), S. 261-271 
    ISSN: 1432-1459
    Keywords: Fusimotor endings ; Acetylcholinesterase ; Parkinsonism ; Motor neuron disease ; Myasthenia ; Muscle spindles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In Serienschnitten wurden die motorischen Endplatten der intrafusalen Muskelfasern in Muskelspindeln von Patienten mit Parkinsonismus, myatrophischer Lateralsklerose und Myasthenia gravis mittels Acetylcholinesterasereaktion untersucht. Beim Parkinsonismus erschienen die diffusen Endigungen, von welchen angenommen wird, daß sie die Endigungen des Gammafasersystemes darstellen, nennenswert verbreitert, während die en-plaque- und en-grappe-Endigungen atrophisch erschienen. In den Fällen von myatrophischer Lateralsklerose erwiesen sich en-plaque- und en-grappe-Endigungen, von welchen angenommen wird, daß sie zu den Betaneuronen und den dynamischen Gammafasern gehören, als ausgesprochen atrophisch. Die diffusen Endigungen allerdings waren normal. Bei Myasthenia gravis und dem myasthenischen Syndrom von Eaton-Lambert zeigten en-plaque- und engrappe-Endigungen Atrophien, während einzig die diffusen Endigungen ausgespart blieben. Es wird die Bedeutung dieser Veränderungen diskutiert.
    Notes: Summary Pathological changes of the fusimotor endings in parkinsonism, motor neuron disease and myasthenia were examined by the acetylcholinesterase technic on serial sections. In parkinsonism, the diffuse endings, which are thought to be supplied by the static gamma nerve fibers, showed remarkable enlargement, while en plaque and en grappe endings were atrophic. In motor neuron disease, en plaque and en grappe endings, which are thought to be innervated by the beta nerve fibers and dynamic gamma nerve fibers respectively, revealed marked atrophy. However the diffuse endings were normal. In myasthenia gravis and myasthenic syndrome (Eaton-Lambert syndrome), en plaque and en grappe endings were atrophic, though only the diffuse endings were spared. The significance of these changes in the fusimotor endings is discussed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...