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  • 1
    Electronic Resource
    Electronic Resource
    Role of serotonin in memory: facilitation by alaproclate and zimeldine (1984)
    Springer
    Psychopharmacology 84 (1984), S. 496-502 
    Details
    ISSN: 1432-2072
    Keywords: Alaproclate ; Zimeldine ; Memory retrieval ; Passive avoidance ; Serotonin ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of alaproclate and zimeldine on memory retrieval were examined in male Swiss Webster mice using a one-trial inhibitory avoidance task. All drugs were administered IP prior to the retention test 24 h after training. Both drugs were found to facilitate memory retrieval significantly in a dose-and time-dependent fashion that could not be explained in terms of non-specific effects of the drug (illness, lack of motility, etc.) at the time of the test. The temporal effects of alaproclate and zimeldine on memory closely followed their course of concentration of the drug within the blood stream. The facilitation of retrieval induced by alaproclate and zimeldine was blocked by the putative serotonergic receptor agonist quipazine but not blocked by the antagonist cyproheptadine. Pretreatment with quipazine alone in a group of animals trained to a shock level which normally results in high levels of suppression was not sufficient to produce memory impairment, suggesting that quipazine was probably antagonizing the facilitative effects of alaproclate and zimeldine directly, rather than overriding the facilitation through an indirect action on retrieval in general. The present results lend further support to the suggestion that serotonin plays a significant role in memory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431456
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Enhancement of the memory of a previously learned aversive habit following pre-test administration of a variety of serotonergic antagonists in mice (1986)
    Springer
    Psychopharmacology 90 (1986), S. 24-27 
    Details
    ISSN: 1432-2072
    Keywords: Memory ; Retrieval ; Serotonin ; Receptor antagonists ; Inhibitory avoidance ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study examined the effects of pre-test administration of a number of serotonergic receptor antagonists on the retrieval of a previously learned aversive habit in the mouse. All of the receptor antagonists (pirenperone, ketanserin, mianserin, methysergide and metergoline) produced a dose-dependent increase in the latency to complete 5 s of drinking 48 h after training. This suppression of drinking could not be attributed to nonspecific effects of the drugs on behavior (e.g., illness, reduced thirst, or activity), as non-contingently trained mice failed to exhibit similar elevations in their test scores. These results are, therefore, further support for an important role for serotonin in the processes underlying learning and memory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172866
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    MR/Har and MNRA/Har Maudsley rat strains: Differences in acoustic startle habituation (1988)
    Springer
    Behavior genetics 18 (1988), S. 663-669 
    Details
    ISSN: 1573-3297
    Keywords: Maudsley rat strains ; response habituation ; acoustic startle ; anxiety ; emotionality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Female Maudsley Reactive (MR/Har) and Nonreactive (MNRA/Har) rats were tested for initial acoustic startle reactivity and within-session startle habituation. Subjects were exposed in each of five weekly sessions to 12 acoustic startle noise bursts at a 20-s interstimulus interval, a procedure in which genetically heterogeneous Sprague Dawley rats have been shown to exhibit robust within-session habituation. Although initial startle reactivity was comparable in the two strains, significant differences in withinssession habituation were observed. Specifically, MR/Har rats were observed to exhibit substantial within-session habituation to these acoustic stimuli, while rats of the MNRA/Har strain exhibited little, if any, habituation to these repeated acoustic stimuli. The basis for this dramatic difference in within-session startle habituation in these Maudsley rats is at present unexplained and under investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01066848
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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