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  • 1
    Electronic Resource
    Electronic Resource
    The gastric cytoprotective action of adenosine and prostaglandin E2 in rabbits (1994)
    Springer
    Inflammation research 42 (1994), S. 146-148 
    Details
    ISSN: 1420-908X
    Keywords: Adenosine ; Prostaglandin E2 ; Gastric gland ; Damage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The direct protective action of adenosine and prostaglandin E2 (PGE2) was examined in an isolated gastric gland preparation in rabbits. Ethanol, (8%, v/v) incubation markedly increased the release of lactate dehydrogenase (LDH) and number of non-viable glands in the preparation. Both effects were prevented by PGE2 preincubation in a concentration (10−6, 1.4×10−5 or 2.8×10−5 M)-dependent manner. The protective action was smaller in adenosine-treated groups, and yet the highest concentration (10−4 M) of the compound also significantly inhibited the cytotoxic effects of ethanol. These findings indicate that both adenosine and PGE2 possess cytoprotective action on gastric glands in rabbits, but the former compound exerts its action beyond physiological concentrations. It is concluded that endogenous PGE2, but not adenosine may act as an ulcer modulator in the stomach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983481
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of nicotine on ethanol-induced gastric ulcers in rats (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1140-1141 
    Details
    ISSN: 1420-9071
    Keywords: Nicotine ; ethanol ; gastric ulcers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Nicotine, in concentrations of 5 and 25 μg/ml drinking water, given ad libitum for 10 days, dose-dependently increased lesion formation and worsened ethanol-induced ulceration in rat stomachs. Daily fluid intake and b.wt gain were not adversely affected by nicotine pretreatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951697
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The influence of chronic nicotine treatment on stress-induced gastric ulceration and emptying rate in rats (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 389-391 
    Details
    ISSN: 1420-9071
    Keywords: Nicotine ; cold-restraint stress ; gastric ulcers and motility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Ten-day treatment with nicotine, (5, 25 or 50 μg/ml drinking water) dose-dependently intensified gastric ulceration induced by cold-restraint, and emptying rate. Stomach contractions produced by graded doses of bethanechol i.v. were elevated further by nicotine treatment. It is suggested that chronic nicotine administration produces hypersensitivity of the gastric muscarinic receptors; stomach hypermotility contributes to the ulcer-worsening action of the alkaloid
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923437
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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