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  • 1
    ISSN: 1432-2072
    Keywords: Nicotine ; Intraventricular ; State-Dependent Behaviour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to choose between the side compartments of a three-chambered shock-escape apparatus according to whether they were injected with nicotine or saline. Half of the rats learned to discriminate between 0.4 mg/kg nicotine and saline administered subcutaneously, whereas the other half learned to differentiate between 644 ng nicotine or saline administered intraventricularly. The rats trained by the subcutaneous route of administration had the ability to discriminate between nicotine and saline given intraventricularly and the rats trained by the intraventricular route could differentiate when the two substances were injected subcutaneously. This transfer of state-dependent control of discriminative behaviour between subcutaneously and intraventricularly administered nicotine and saline is presented as evidence for the central origin of the nicotine-produced interoceptive cue.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2072
    Keywords: Nicotine ; State-Dependent Behavior ; Lobeline ; Amphetamine ; Arecoline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to enter one arm of a T-maze after the subcutaneous administration of 0.4 mg/kg and to enter the opposite arm following the injection of an equal volume of saline. Administration of 0.4 mg/kg nicotine isomethonium iodide hydroiodide, 0.4–10.0 mg/kg lobeline sulfate, 2.0 and 4.0 mg/kg d-amphetamine sulfate and 0.25–2.0 mg/kg arecoline hydrobromide produced responses which resembled the established saline effect. Pretreatment with 10.0 mg/kg lobeline had no significant effect on the nicotine-cued response. The inability of these structurally and/or functionally similar drugs to produce a nicotine-like discriminative effect is discussed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 24 (1972), S. 417-429 
    ISSN: 1432-2072
    Keywords: State-Dependent Learning ; Nicotine ; 5-Hydroxytryptamine ; Norepinephrine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to make a specific behavioral response in a T-maze apparatus conditional upon whether they were injected with 0.4 mg/kg nicotine or saline. Depletion of brain levels of 5-hydroxytryptamine by orally administered para-chlorophenylalanine had no significant effect on the rats' ability to discriminate nicotine. However, both insoluble alpha-methyl-p-tyrosine and its ester, at intraperitoneal doses of 90 and 135 mg/kg, respectively, significantly decreased discrimination of nicotine at 180 and 270 min post-administration. At these doses and times, saline discrimination was not altered. The experimental evidence indicates that nicotine's CNS cueing effect is mediated by norepinephrine, and this is discussed in light of the Burn and Rand hypothesis. It is proposed that, nicotine may act on a specific nicotine-sensitive cholinergic receptor in the CNS, which causes release of norepinephrine which, in turn, produces the interoceptive cueing effect that enables the rats to make the appropriate behavioral response.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 335 (1993), S. 214-215 
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 337 (1995), S. 424-424 
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 340 (1998), S. 585-585 
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 337 (1995), S. 164-165 
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 9 (1995), S. 809-814 
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The aim of this article was to study the influence of different matrix molecules on the quality of matrix-assisted laser desorption/ionization mass spectra of oligosaccharides. An important criterion was the sample preparation, i.e. the crystallization process leading to the matrix from which the analytes were desorbed and investigated. Quality criteria were, among others, the resulting molecular peak intensity, the mass resolution, and the suppression of unwanted matrix peaks. It was found that a mixture of 2,5-dihydroxy benzoic acid (DHB) and 1-hydroxy isoquinoline (HIC) in a weight ratio of 3:1 was best suited for the analytical investigation of oligosaccharides. In addition, this matrix mixture was found to be quite tolerant against all kinds of buffers, salts, and even additives such as sodium dodecyl sulfate (SDS). Furthermore, we determined the different affinities of the alkaline metals to the carbohydrates and found that cesium and potassium ions ionize oligosaccharides about three times better than sodium ions and therefore have an important influence on the quantum yield.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: A Nafion membrane was tested as a new tool for a fast and easy sample pretreatment for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) measurements. This membrane material was used for ion exchange and carbohydrate purification with minimal quantities of sample solution. An ion exchange method for carbohydrates was developed and demonstrated on a Dextran sample. The cations of the original sample were replaced within minutes by potassium or cesium ions. Another feature of this membrane was the fact that proteins and peptides adsorb on the acid surface. This behavior was investigated as a purification step for carbohydrates with high peptide and protein impurity concentrations. It was found that oligosaccharide libraries from rat- and mouse IgG mass spectra can be obtained clearly in the presence of high peptide impurities.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 37 (1989), S. 3029-3056 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: This study was undertaken to determine how milled glass fibers affect the fatigue resistance of reaction injection molded (RIM) nylon 6. Specifically the effects of glass content, fiber length, orientation, and surface treatment were investigated. The fatigue crack growth rates for unfilled and glass-filled samples were observed to follow the well-known Paris equation in terms of dependence on cyclic stress intensity factor. For the unfilled nylon a line shaped zone was observed in advance of the crack tip. Fractography results suggest that the zone was the projection of the actual crack tip profile through the thickness of the sample rather than a distinct plastic or deformation zone. The fatigue fracture surface exhibited a patchy type structure with features 50-150 μm in size, suggesting a void coalescence type of mechanism as has been reported for injection molded nylons. A diffuse damage zone, several millimeters in size, was observed at the crack tip for the glass-filled RIM nylon 6. The zone was observed to pulsate with the applied oscillating load. The growth of the damage zone volume with increasing crack length (and thus increasing stress intensity factor range) followed the Paris law, as did the crack growth rate data. The damage mechanism is attributed to void formation and microcracking at the fiber-matrix interface. The results of this study show that, for milled glass-reinforced RIM nylon 6, the crack growth rates were much more rapid than observed for injection-molded nylon 6 containing chopped glass fibers. This difference is attributed to the greatly reduced glass fiber lengths for the milled glasses.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
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