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  • 1
    Digitale Medien
    Digitale Medien
    The use of radionuclide techniques in the assessment of alveolar-capillary membrane permeability on the intensive care unit (1990)
    Springer
    Intensive care medicine 16 (1990), S. 363-371 
    Details
    ISSN: 1432-1238
    Schlagwort(e): Intensive care ; Radionuclides ; Lung injury
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Conclusion Three isotopic methods of estimating alveolar-capillary membrane permeability have been described. The first, radiolabelled HSA, is crude, and appears to have no clinical applications. Pulmonary99mTc-DTPA clearance studies are relatively easy to perform, but suffer from their high sensitivity and variations in technique from centre to centre. The double isotopic measurement of PAI has only been adopted by a few centres, but may offer reliable assessment of the pulmonary endothelial permeability which is probably an early marker of acute lung injury. None of these techniques has proved predictive of outcome in ARDS. However, trials where alveolar-capillary membrane permeability is assessed before clinical evidence of lung injury is apparent have yet to be conducted. Thus at present, methods of assessing alveolar-capillary membrane permeability, particularly capillary endothelial integrity, may prove to be more useful in monitoring new therapeutic interventions in lung injury, rather predicting outcome.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01735173
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  • 2
    Digitale Medien
    Digitale Medien
    Is bleomycin-detectable iron present in the plasma of patients with septic shock? (1997)
    Springer
    Intensive care medicine 23 (1997), S. 635-639 
    Details
    ISSN: 1432-1238
    Schlagwort(e): Key words Septicaemia ; Bleomycin-detectable iron ; Non-haem iron ; Iron overload
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective: To assess plasma iron status in critically ill patients with septic shock. Design: Observational, prospective study. Setting: Adult intensive care units in teaching and tertiary referral hospitals. Patients and participants: Fifteen adult patients with established septic shock. Normal control subjects (n = 10) were also investigated. Data from patients and controls were compared with previously published iron values in critical care patients. Measurements and results: The indices investigated and correlated with clinical scores of illness severity included bleomycin-detectable iron, non-haem iron; transferrin and its percentage iron saturation, and the iron binding (anti-oxidant) activity of transferrin. Bleomycin-detectable iron was not present in the plasma of patients with septic shock whilst the plasma transferrin remained unsaturated with iron. One patient in multi-organ failure displayed bleomycin-detectable iron in plasma (1.16 μmol/l) and had 100 % iron-saturation of transferrin. The plasma non-haem iron levels (7.84 ± 1.82 μmol/l) were the lowest of all critical care patient groups studied by us. The plasma transferrin levels were also low but resulted in a near normal percentage saturation of transferrin with iron (34.6 ± 6.5 %). The scores of clinical severity correlated with changes in plasma iron chemistry. Conclusions: Patients with septic shock rarely have iron saturated transferrin in their plasma leading to the presence of bleomycin-detectable iron.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001340050386
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  • 3
    Digitale Medien
    Digitale Medien
    Transpulmonary gradient of type III procollagen peptides: Acute effects of cardio-pulmonary bypass (1992)
    Springer
    Intensive care medicine 18 (1992), S. 290-292 
    Details
    ISSN: 1432-1238
    Schlagwort(e): Procollagen peptides ; Cardiopulmonary bypass
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Type III procollagen N-peptides (PIIINPs) are believed to be released in stoichiometric amounts as type III collagen molecules are secreted from cells. We hypothesized that if the human lung actively produces type III collagen a detectable transpulmonary gradient in PIIINPs would exist in normal individuals that might be altered following a pulmonary insult. PIIINPs were therefore measured by radioimmunoassay in serum taken simultaneously from the pulmonary artery (PA) and left ventricle/aorta (LV) in 11 patients undergoing routine cardiac catheterisation. Mean PIIINP levels±SEM in LV were 66.8±5.4 μg·ml−1 and 59.9±4.1 μg·ml−1 in PA (p〈0.04). In 6 patients, repeat measurements taken 4 h after cardiopulmonary bypass revealed a significant fall in PA values to 43.8±2.6 μg·ml−1 (p〈0.001) and abolition of the transpulmonary gradient. These results suggest the adult human lung actively synthesis type III collagen and that, in the short term, cardiopulmonary bypass inhibits this process.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01706477
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