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  • 1
    ISSN: 1432-1912
    Keywords: Secretoneurin ; Noradrenaline ; Large dense core vesicles ; Calcium channel blockers ; Secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Secretoneurin is a newly discovered peptide found in high concentrations in brain. We have studied the release of secretoneurin and noradrenaline from superfused hypothalamic slices from rat brain. Both electrical stimulation and potassium induced depolarisation released secretoneurin and noradrenaline from these slices in a calcium-dependent manner. Electrical stimulation caused a preferential release of noradrenaline when compared to the secretion elicited by high potassium. The time course of secretoneurin release was more protracted than that of noradrenaline. The calcium channel blocker ω-conotoxin inhibited only the electrically induced release of noradrenaline, whereas nifedipine inhibited only that of secretoneurin. These results establish that secretoneurin is secreted from neurons. Inhibition of this release by nifedipine is consistent with the concept that secretion from large dense core vesicles occurs at sites different from that of small vesicles and depends on calcium influx via L-type calcium channels.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Rheumatologie 59 (2000), S. 86-92 
    ISSN: 0340-1855
    Keywords: Schlüsselwörter Rheumafaktor –¶Immunisierung –¶Gesunde Erwachsene ; Key words Rheumatoid factor – immunization – healthy individuals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A forty year old healthy adult man was admitted to our out-patient department because of a highly elevanted rheumatoid factor. Since the person was planning an extended stay in Africa, we performed an extensive history, clinical and laboratory examination to rule out oligosymptomatic inflammatory diseases. We further analyzed if the person presented genetic risk factors to develop rheumatic diseases in the future or if the presence of the rheumatoid factor could be a reaction to multiple immunizations. Possible explanations for an elevated rheumatoid factor including the genetic risk factors are discussed.
    Notes: Zusammenfassung Ein gesunder 40jähriger Mann wurde wegen eines hohen Rheumafaktors in unserer Ambulanz vorgestellt. Da der Betroffene einen mehrmonatigen Auslandsaufenthalt in Afrika plante, wurden eine ausführliche Anamnese, klinische und laborchemische Untersuchungen durchgeführt. Die Vorstellung erfolgte zum Ausschluss einer oligosymptomatischen rheumatischen Erkrankung, zur Frage nach genetischen Risikofaktoren eine solche zu entwickeln, und zur Frage, ob Rheumafaktoren als Impfreaktion auftreten können; diese Aspekte werden diskutiert.
    Type of Medium: Electronic Resource
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