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  • 1
    Electronic Resource
    Electronic Resource
    Hohe Rheumafaktorentiter durch Vakzination? (2000)
    Springer
    Zeitschrift für Rheumatologie 59 (2000), S. 86-92 
    Details
    ISSN: 0340-1855
    Keywords: Schlüsselwörter Rheumafaktor –¶Immunisierung –¶Gesunde Erwachsene ; Key words Rheumatoid factor – immunization – healthy individuals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A forty year old healthy adult man was admitted to our out-patient department because of a highly elevanted rheumatoid factor. Since the person was planning an extended stay in Africa, we performed an extensive history, clinical and laboratory examination to rule out oligosymptomatic inflammatory diseases. We further analyzed if the person presented genetic risk factors to develop rheumatic diseases in the future or if the presence of the rheumatoid factor could be a reaction to multiple immunizations. Possible explanations for an elevated rheumatoid factor including the genetic risk factors are discussed.
    Notes: Zusammenfassung Ein gesunder 40jähriger Mann wurde wegen eines hohen Rheumafaktors in unserer Ambulanz vorgestellt. Da der Betroffene einen mehrmonatigen Auslandsaufenthalt in Afrika plante, wurden eine ausführliche Anamnese, klinische und laborchemische Untersuchungen durchgeführt. Die Vorstellung erfolgte zum Ausschluss einer oligosymptomatischen rheumatischen Erkrankung, zur Frage nach genetischen Risikofaktoren eine solche zu entwickeln, und zur Frage, ob Rheumafaktoren als Impfreaktion auftreten können; diese Aspekte werden diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003930050209
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  • 2
    Electronic Resource
    Electronic Resource
    No direct correlation between HLA-DPB1 and antibodies against recombinant Ro (SS-A)/La (SS-B) proteins in systemic lupus erythematosus (1993)
    Springer
    Rheumatology international 13 (1993), S. 155-158 
    Details
    ISSN: 1437-160X
    Keywords: Systemic lupus erythematosus ; HLA-DP ; Ro (SS-A) autoantibodies ; La (SS-B) autoantibodies ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated the association of HLA-DPB1 alleles with the occurrence of autoantibodies against Ro (SS-A) or La (SS-B) using recombinant 52kD-Ro, 60 kD-Ro and La proteins in 177 German patients with systemic lupus erythematosus (SLE). A significant increase in the frequency of DPB1 *0101 is observed in SLE patients compared to healthy controls (P corr.〈0.004). Antibodies against 52 kD-Ro, 60 kD-Ro and La are tested by ELISA and are found with a frequency of 25.4%, 33.9% and 17.5% in the patients, respectively. An association with HLA-DPB1 *0101 is observed for antibodies against La (P〈0.01) and 52 kD-Ro (P〈0.01), but not for 60 kD-Ro in the absence of La/52 kD-Ro. Since there is a strong linkage disequilibrium between DPB1 *0101 and DR3 in the normal population and in SLE patients, and since there is an association between DR3 and SLE, as well as between DR3 and the occurrence of recombinant Ro/La antibodies in SLE patients, we investigated whether DPB1 *0101 is associated per se or via linkage disequilibrium with DR3. DPB1 *0101 in the absence of DR3 is not more common in patients than in controls and not in patients with autoantibodies to Ro and La than without antoantibodies. We conclude that there is no evidence for a direct involvement of DPB1 *0101 in the production of Ro/La autoantibodies in SLE patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301263
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  • 3
    Electronic Resource
    Electronic Resource
    The genetic basis of Ro and La antibody formation in systemic lupus erythematosus (1992)
    Springer
    Rheumatology international 11 (1992), S. 243-249 
    Details
    ISSN: 1437-160X
    Keywords: Systemic lupus erythematosus ; Ro and La antibodies ; Multicenter study ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antibodies against Ro and La, including recombinant La and recombinant 60 kD-Ro, were determined by counter immunoelectrophoresis and ELISA in over 300 central European systemic lupus erythematosus (SLE) patients. The presence of both Ro and La antibodies was strongly associated with the MHC haplotype B8-C4AQ0-DR3-DQ2, the association being stronges for DR3. After exclusion of all B8-DR3 positive patients only DR3 positive patients still showed an increased incidence of Ro and La antibodies, suggesting DR3 as the primary association factor. High titers of La antibody, but not of 60 kD-Ro antibody, were also significantly associated with the presence of DR3. Other DR and DQ antigens or heterozygous DQ combinations were not significantly associated with Ro and La antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301501
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  • 4
    Electronic Resource
    Electronic Resource
    HLA class II genes and antibodies against recombinant U1-nRNP proteins in patients with systemic lupus erythematosus (1994)
    Springer
    Rheumatology international 14 (1994), S. 63-69 
    Details
    ISSN: 1437-160X
    Keywords: Systemic lupus erythematosus ; Recombinant U1-nRNP proteins ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate a possible involvement of HLA-class II alleles in the genetic predisposition for the formation of anti-U1-nRNP antibody in systemic lupus erythematosus (SLE), genomic DNA of 178 patients was typed for the DRB1, DQA1 and DQB1 alleles using a polymerase chain reaction (PCR) and non-radioactive-oligonucleotide typing. Antibodies against recombinant U1-nRNP proteins (U1-A- U1-C-and 70K-protein) were determined by ELISA. Anti-U1-C antibody was found in 26 (14.7%), anti-U1-A in 34 (19.2%) and anti-70K in 17 (9.6%) patients. A joint occurrence was observed for these antibodies against the recombinant U1-nRNP proteins: anti-U1-C and anti-U1-A antibodies occurred together more frequently than alone and than together with anti-U1-70K antibodies. The frequency of DRB1 * 04 was slightly increased in the patients with anti-U1-C as compared to the patients without anti-U1-C (P〈0.05, Pcorr=n.s., RR=2.4). The DQA1 * 0301 allele, which is in linkage disequilibrium with DRB1 * 04, is found more frequently in anti-U1-C-positive than in antibody-negative patients. The DQB1 * 0303 allele, detected in 12 of 176 SLE patients, was absent in the patients with any of the antibodies against the U1-nRNP proteins. All these deviations may be due to chance alone. We concluded that the presence of antibodies against recombinant U1-nRNP proteins was not significantly associated with any HLA DRB1, DQA1 and DQB1 allele in our group of SLE patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300249
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  • 5
    Electronic Resource
    Electronic Resource
    MHC associations of autoantibodies against recombinant Ro and La proteins in systemic lupus erythematosus (1992)
    Springer
    Rheumatology international 12 (1992), S. 169-173 
    Details
    ISSN: 1437-160X
    Keywords: Systemic lupus erythematosus ; Genetics ; Ro and La antibodies ; Recombinant autoantigens ; MHC ; Multicenter study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antibodies against recombinant 52 kD-Ro, recombinant 60 kD-Ro and recombinant La protein were determined by ELISA in over 300 central European patients with systemic lupus erythematosus (SLE). A strong association with HLA-DR3 was found for antibodies against 52 kD-Ro and La, but not for recombinant 60 kD-Ro antibodies in the absence of antibodies against 52 kD-Ro or La. Ro/La negative SLE patients still showed an increased frequency of HLA-DR3 as compared to healthy controls. These results indicated that the preferential formation of Ro and La antibodies was not due to an unspecific stimulatory effect of HLA-DR3 but that the antibody response to certain defined proteins (52 kD-Ro and La) was influenced by MHC genes in SLE. Furthermore, the association of SLE with HLA-DR3 was independent of the effects of DR3 on the formation of 52 kD-Ro and La antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302148
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  • 6
    Electronic Resource
    Electronic Resource
    Tick-borne encephalitis in the Saarland and the Rhineland-Palatinate (1996)
    Springer
    Infection 24 (1996), S. 242-244 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Saarland und Rheinland-Pfalz gelten nicht als Frühsommer-Meningoenzephalitis (FSME)-Endemiegebiete. Daher wurde in dieser Region nicht zu einer Impfung gegen FSME geraten und es wurde auch nur selten serologisch auf diese Krankheit untersucht. 1994 wurde in Baden-Württemberg eine deutliche Zunahme der Erkrankungsfälle registriert. Ferner wurde in diesem Jahr die erste im Saarland erworbene FSME dokumentiert. Zur Klärung der Frage, wie hoch das Infektionsrisiko für TBE im Saarland und Rheinland-Pfalz ist, wurden seit 1989 durchgeführte 2123 serologische FSME-Untersuchungen aufgearbeitet und 904 tiefgefrorene Seren von Patienten mit entzündlichen Liquorveränderungen serologisch nachuntersucht. Bei insgesamt 15 Patienten fanden wir IgG- und IgM-Antikörper gegen den Erreger der FSME. 4 Fälle wurden klinisch und serologisch als FSME gesichert, wobei eine Erkrankung sicher und eine weitere wahrscheinlich im Saarland erworben wurden. Bei drei weiteren Patienten fanden wir serologische Hinweise auf einen FSME-Virus Kontakt. Die Untersuchungsergebnisse legen den Verdacht nahe, daß im Saarland mit vereinzelten Erkrankungsfällen gerechnet werden muß. Das Infektionsrisiko ist jedoch sehr gering.
    Notes: Summary The Saarland and the Rhineland-Palatinate are not considered endemic regions for tick-borne encephalitis (TBE), and patients in this region have not been routinely advised to undergo vaccination or serologic testing for TBE. In 1994, a significantly increased incidence of TBE cases was noted in the neighbouring state of Baden-Württemberg. In the same year, the first TBE acquired in the Saarland was diagnosed. To investigate the infection risk for TBE in the Saarland and Rhineland-Palatinate, the records of 2,123 serologic tests for TBE collected since 1989 were systematically examined. In addition, 904 frozen sera of patients displaying inflammatory changes in the cerebrospinal fluid (CSF) were analyzed. IgG and IgM antibodies against TBE virus were found in 15 patients, four of which were verified clinically and serologically as TBE. One of these four cases was certainly and another was probably acquired in the Saarland. Three other patients displayed serologic signs of a TBE virus contact. The results of this study suggest that the occurrence of single cases in the Saarland has to be considered, but the risk is very small.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01781102
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