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  • 1
    Electronic Resource
    Electronic Resource
    Polychemotherapy of acute myelogenous leukemia in a patient with acute intermittent porphyria (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 338-340 
    Details
    ISSN: 1432-1440
    Keywords: Porphyria ; Chemotherapy ; Acute myelogenous leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The safety of drugs in hepatic porphyrias has largely been established by clinical experience, which is very limited in the case of antineoplastic agents. We administered three cycles of polychemotherapy consisting of daunorubicin, cytarabine and 6-thioguanine, and modified supportive care to a 33-year-old Turkish woman suffering from acute myelogenous leukemia. The urinary excretion of total porphyrins, porphobilinogen, and aminolevulinic acid was continuously monitored. Excreation of these metabolites was permanently elevated, but the values were comparatively low during cytotoxic therapy while peak values were recorded at the onset of fever during bone marrow aplasia; yet there were no clinical signs of porphyritic attacks at that time. A few potentially unsafe drugs were tolerated without an increase in porphyrin excretion. Although the susceptibility to drugs is highly variable in patients with hepatic porphyrias, the treatment of malignancy in these patients seems justified as long as porphyrin excretion under therapy is not grossly elevated over baseline values and appropriately modified supportive care is administered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745391
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of rhGM-CSF on haematopoietic reconstitution after chemotherapy in small-cell lung cancer (1991)
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. S203 
    Details
    ISSN: 1432-1335
    Keywords: rhGM-CSF ; Small-cell lung cancer ; Chemotherapy ; Haemopoietic recovery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In three consecutive pilot studies the effect of recombinant human granulocyte/macrophage-colony-stimulating factor (rhGM-CSF) on haematopoetic recovery after chemotherapy in patients with small-cell lung cancer was investigated. In study I, 20 patients received AIO chemotherapy (A, Adriamycin 25 mg/m2 on days 1+2; I, ifosfamide 2 g/m2 on days 1–5; O, vincristine 2 mg on day 1) at 4-week intervals either with or without rhGM-CSF (250 μg/m2 sc) from day 8 until recovery of leucocytes. Neither the degree nor the duration of myelosuppression was markedly influenced by rhGM-CSF. Suggesting that these disappointing results were caused by the late onset of GM-CSF application, in the following study we shortened chemotherapy to 3 days and started with GM-CSF on day 4. The main objective of this study was to test whether the earlier administration of GM-CSF allowed treatment intervals to be reduced or the dose to be escalated. After 10 patients had received a starting dose of AIO (A, 50 mg/m2 on day 1; I, 2 g/m2 on days 1–3; 0,2 mg on day 1) alternating with cisplatin (90 mg/m2 on day 1) and etoposide (150 mg/m2 on days 1–3), the dose of ifosfamide and etoposide was escalated to 2.5 g/m2 on days 1–3 and 200 mg/m2 on days 1–3 in the next 10 patients. Treatment was given at 2-week intervals when leucocytes were 〉 3500/mm3 and thrombocytes were 〉 100 000 mm3 on day 14. At each dose level patients were randomized to receive either rhGM-CSF 250 μg/m2 s.c. on days 4–12 or no GM-CSF. In this study, rhGM-CSF markedly shortened the duration of leukopenia. Reinstitution of chemotherapy on day 15 was possible at dose level 1 in 1/4 patients without and in 3/4 patients with GM-CSF, and at dose level 2 in 0/5 patients without and in 5/5 patients with GM-CSF. However, the degree of myelosuppression was not improved by GMCSF. In a third study we tried to apply rhGM-CSF simultaneously with chemotherapy. After 3 patients had received GM-CSF starting on day 1 concurrent to AIO chemotherapy, we noticed an increase of myelosuppression with prolonged neutropenia and thrombocytopenia and stopped this investigation. Considering all patients included in these three consecutive pilot studies, there is no difference in response rates and survival between patients with and without rhGM-CSF treatment. Optimal scheduled rhGM-CSF application shortens the period of myelosuppression and allows reinstitution of chemotherapy at 2-week intervals. Whether these modifications are able to improve the overall treatment results, has to be determined in future clinical trials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01613228
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  • 3
    Electronic Resource
    Electronic Resource
    Poly[(4-N-ethylene-N-ethylamino)-α-cyanocinnamate]: A nonlinear optical polymer with a chromophoric mainchain. I. Synthesis and spectral characterization (1991)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 29 (1991), S. 1623-1631 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Poly[(4-N-ethylene-N-ethylamino)-α-cyanocinnamate] was prepared by solution esterification of (4-N-ethyl-N-(2-hydroxyethyl) amino)-α-Cyanocinnamic acid and by melt transesterification of ethyl (4-N-ethyl-N-(2-hydroxyethyl) amino)-α-cyanocinnamate. The melt transesterification generally yielded polymer with a number-average molecular weight of about 10,200 by gel permeation chromatography (GPC) versus polystyrene standards. The polymer was found to be amorphous with a glass transition temperature of about 103°C by differential scanning calorimetry (DSC). The solution esterification generally gave a polymer with a number-average molecular weight of about 2200 by GPC versus polystyrene standards. This polymer was found to have a glass transition temperature varying between 60 and 90°C by DSC. The infrared (IR) spectrum of the polymer made from both methods were analyzed in detail. The 1H- and 13C-NMR spectra of the meltsynthesized ethyl cinnamate derivative polymer are consistent with the reported structure.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1991.080291112
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  • 4
    Electronic Resource
    Electronic Resource
    Die galvanische Verchromung. Leitfaden für die moderne Glanz- und Hartverchromung von R. Weiner. DIN A 5. Bd. 6 der „Schriftenreihe Galvantechnik“ Eugen G. Leuze-Verlag, Saulgau/Württ. 1961. 182 S. mit 52 Abb. und 18 Tab. Halbleinen DM 16.50. Für Bezieher aller Bände dieser Reihe gilt der Vorzugspreis von DM 14,50 (1961)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 12 (1961), S. 795-795 
    Details
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/maco.19610121214
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  • 5
    Electronic Resource
    Electronic Resource
    Die Betriebsüberwachung und Untersuchung galvanischer Bäder und Niederschläge. Von H. Krause. Carl Hanser-Verlag, München 1959, 3. verbesserte Auflage, 281 S., 97 Abb., Leinen DM 19,80 (1960)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 11 (1960), S. 75-75 
    Details
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/maco.19600110116
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  • 6
    Electronic Resource
    Electronic Resource
    Vom Hand- und Automatenpolieren. W. Burkart (in der Schriftenreihe Galvanotechnik, Herausgeber: R. Weiner). E. G. Leuze Verlag, Saulgau/Wttbg. 1959, 109 S., 113 Abb., Geb. DM 8,50 (für Bezieher aller Bücher der Schriftenreihe DM 7,50) (1960)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 11 (1960), S. 76-76 
    Details
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/maco.19600110118
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  • 7
    Electronic Resource
    Electronic Resource
    Kinetik der radikalischen copolymerisation α-substituierter styrole mit styrol. 1. Teil. Copolymerisation von α-methylstyrol mit styrol oberhalb der ceiling-temperatur von α-methylstyrol (1972)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 155 (1972), S. 211-225 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: The radical copolymerization of α-methylstyrene with styrene in the temperature range from 60 to 150°C can be described according to the equations derived by WITTMER with the assumption, that the addition steps of α-methylstyrene may be reversibel.For the temperature range from 60 to 110°C it could be demonstrated that it would be sufficient to consider only the reversibility of the addition steps of α-methylstyrene to a radical end with α-methylstyrene as the terminal unit. At a reaction temperature of 150°C the addition of α-methylstyrene to a styryl chain end is also reversible, the equilibrium constant being only 1/30 of the α-methylstyrene homopolymerization.The retardation of the polymerization rate by admixture of small amounts of α-methylstyrene to styrene was measured. The results allow an estimation of the rate constants and activation energies of the chain propagation and depolymerization steps.
    Notes: Die radikalische Copolymerisation von α-Methylstyrol mit Styrol läßt sich im Temperaturbereich von 60-150°C nach Gleichungen beschreiben, die WITTMER unter der Annahme abgeleitet hat, daß die Additionsreaktionen von α-Methylstyrol reversibel sein können.Hierbei genügt es, im Temperaturbereich von 60-110°C lediglich die Reversibilität von α-Methylstyrol-Additionsschritten an ein Kettenende mit α-Methylstyrol als letzter Monomereinheit zu berücksichtigen. Für 150°C als Reaktionstemperatur ergibt sich, daß auch die Addition von α-Methylstyrol an ein Styryl-Kettenende meßbar reversibel ist, jedoch mit einer Gleichgewichtskonstante, die um einen Faktor 30 unter der für die α-Methylstyrol-Homopolymerisation liegt.Aus der Retardierung der Styrolpolymerisation durch geringe Zusätze von α-Methylstyrol werden die einzelnen Geschwindigkeitskonstanten und Aktivierungsenergien des Kettenwachstums und der Depolymerisation abgeschätzt.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1972.021550119
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  • 8
    Electronic Resource
    Electronic Resource
    Kinetik der radikalischen copolymerisation α-substituierter styrole mit styrol. 3. Teil. Das zusammenwirken von copolymerisation, retardierung und kettenübertragung in abhängigkeit von der chemischen struktur2. Teil. J. P. FISCHER, s. Seite 227. (1972)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 155 (1972), S. 239-257 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: An einer Serie von zehn teilweise erstmalig synthetisierten α-substituierten Styrolen wird durch kinetische Messungen bei 110°C gezeigt, daß solche Verbindungen zusammen mit Styrol nach dem Mechanismus einer Copolymerisation reagieren, jedoch je nach dem Charakter des α-Substituenten verschieden stark retardieren oder zur Kettenübertragung führen.Hierbei zeigen α-Alkylstyrole kaum Kettenübertragung, jedoch eine um so größere Retardierung, je sperriger der α-Substituent ist. α-Arylalkylstyrole vom Typ 4-substituierter 2.4-Diphenylbuten(1)-derivate führen hingegen zu einer merklichen Kettenübertragung, wie die übertragungskonstanten von 0,29 und 0,26 der Verbindungen 4-Methyl-2.4-diphenylpenten(1)bzw. 2.4.4-Triphenylpenten(1) beweisen.Die einzelnen Geschwindigkeitskonstanten für Kettenwachstum und Kettenübertragung werden berechnet oder größenordnungsmäßig abgeschätzt.
    Notes: The copolymerization of styrene with a series of ten α-substituted styrenes, partially synthesized for the first time, was investigated by kinetic measurements. All compounds react with styrene according to the mechanism of copolymerization. The extent of the observed retardation or chain transfer reaction depends on the chemical nature of the α-substituent.Some α-alkylstyrenes scarcely show chain transfer, yet the more bulky the α-substituent is, the more retardation could be observed. On the other hand α-arylalkylstyrenes of the type of 4-substituted 2.4-diphenyl-1-butene-derivates cause an evident chain transfer as can be seen from the chain transfer constants of 0,29 and 0,26 from 4-methyl-2.4-diphenyl-1-pentene and 2.4.4-triphenyl-1-pentene, respectively.The single rate constants of chain propagation and chain transfer are calculated or estimated.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1972.021550121
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  • 9
    Electronic Resource
    Electronic Resource
    Kinetik der radikalischen copolymerisation α-substituierter styrole mit styrol. 2. Teil. Copolymerisation von styrol mit 1.1-diphenyläthylen1. Teil s. Seite 211. (1972)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 155 (1972), S. 227-238 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: It is shown that the copolymerization of styrene (M1) with 1.1-diphenylethylene (M2) at 110°C can be described by the conventional copolymerization equation with the parameters r1 = 0.34 ± 0.04 and r2 = 0. From these two parameters only r1 follows the Q-e-scheme with Q2 = 2.3 and e2 = -0.35 in the same way as the r1-parameters of other sterically unhindered comonomers of 1.1-diphenylethylene.1.1-Diphenylethylene causes a strong retardation but no inhibition of the styrene polymerization. The quantitative determination of the mentioned retardation leads to the conclusion that the rate constants k12 and k21 of the alternating steps differ at least for two orders of magnitude, k21 as the lower rate constant being responsible for the strong retardation and mainly for the low molecular weights of the copolymers.
    Notes: Für die Copolymerisation von Styrol (M1) mit 1.1-Diphenyläthylen (M2) bei 110°C zeigte sich, daß die konventionelle Copolymerisationsgleichung mit den Parametern r1 = 0,34 ± 0,04 und r2 = 0 zutrifft, wobei der r1-Wert wie für andere sterisch ungehinderte Comonomere des 1.1-Diphenyläthylens das Q-e-Schema mit Q2 = 2,3 und e2 = -0,35 erfüllt.1.1-Diphenyläthylen verursacht eine starke Retardierung, jedoch keine Inhibierung der Styrolpolymerisation. Aus der Retardierung der Styrolpolymerisation bei geringem 1.1-Diphenyläthylengehalt ergibt sich, daß die Geschwindigkeitskonstanten k12 und k21 für die Alternierungsschritte sich um wenigstens zwei Größenordnungen unterscheiden, derart, daß der niedrige k21-Wert sowohl für die starke Retardierung als auch hauptsächlich für die geringen Molekulargewichte der Copolymeren verantwortlich ist.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1972.021550120
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  • 10
    Electronic Resource
    Electronic Resource
    Metallwaren-Industrie und Galvanotechnik, Fachausgabe „Schleifen und Polieren“ 47 (1956) Nr. 9, S. 381/414 (1957)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 8 (1957), S. 177-177 
    Details
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/maco.19570080315
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