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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of sulfate excretion by (aminooxy)acetate induced stimulation of taurine excretion in rats (1995)
    Springer
    Amino acids 8 (1995), S. 345-352 
    Details
    ISSN: 1438-2199
    Keywords: Amino acids ; Cysteine metabolism ; Sulfate formation ; Taurine formation ; Hypotaurine ; Sulfur equilibrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary l-Cysteine is mainly metabolized to sulfate and taurine through cysteinesulfinate pathway. Alternatively, sulfate is formed in rat liver mitochondria via 3-mercaptopyruvate pathway. Intraperitoneal administration of 5 mmol ofl-cysteine per kg of body weight resulted in the increase in sulfate and taurine (plus hypotaurine) excretion in the 24-h urine, which corresponded to 45.3 and 29.3%, respectively, ofl-cysteine administered. Subcutaneous injection of (aminooxy)acetate, a potent inhibitor of transaminases, together withl-cysteine halved the sulfate excretion and doubled the taurine excretion. In vitro sulfate formation froml-cysteine and froml-cysteinesulfinate in rat liver mitochondria was inhibited by (aminooxy)-acetate. The sulfate-forming activity of liver mitochondria obtained from rats injected with (aminooxy) acetate was also inhibited. These results indicate that the transamination reaction is crucial in sulfate formation and in the regulation of sulfur metabolism. Sulfur equilibrium in mammals was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00806552
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  • 2
    Electronic Resource
    Electronic Resource
    Preparation and analysis of a volatile derivative of cysteic acid (1991)
    Springer
    Amino acids 1 (1991), S. 375-378 
    Details
    ISSN: 1438-2199
    Keywords: Amino acids ; Cysteic acid analysis ; Taurine analysis ; Gas chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have reported preparations and gas chromatographic analyses of volatile derivatives of sulfuric acid and taurine (Masuoka et al., 1988; 1989). By extending these studies, we have developed a method for the gas chromatographic determination of cysteic acid. Cysteic acid was converted to the N-isobutoxycarbonyl derivative by the reaction with isobutyl chloroformate in the presence of sodium hydroxide. After desalting with a cation-exchange column, the derivative was converted to the silver salt by reacting with silver oxide. The resulting silver salt was quantitatively esterified with methyl iodide in the presence of dimethyl sulfate and silver oxide. Dimethyl N-isobutoxy-carbonylcysteate [methyl 2-(N-isobutoxycarbonylamino)-3-(methoxysulfonyl) propanoate] formed was analyzed by gas chromatography. The calibration curve was linear up to 5.0µmol per ml of cysteic acid and the recovery was more than 95%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00814006
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Olfactory disturbances caused by the anti-cancer drug tegafur (1995)
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 48-52 
    Details
    ISSN: 1434-4726
    Keywords: Tegafur ; Bromodeoxyuridine ; Proliferating cell nuclear antigen ; Immunohistochemistry ; Cell mitoses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Olfactory disturbances induced by the anticancer drug tegafur were studied in separate clinical and experimental investigations. Five patients with olfactory dysfunction after tegafur were studied and were found to have normal endoscopic findings of the olfactory cleft mucosa. The average period for drug administration was 22 months. Recovery from the olfactory disturbance was poor and biopsy of the olfactory mucosa revealed severely degenerated epithelium. In experimental studies in a guinea pig animal model, effects of oral tegafur on mitotic cells in the olfactory epithelium were examined using bromodeoxyuridine (BrdU) uptake as index. At the conclusion of 3 weeks' treatment, no pronounced morphological changes were seen, but the number of BrdU-incorporating cells decreased in proportion to the dose of tegafur used. Following long-term administration of tegafur 18 months, mitotic cells reacting to BrdU or proliferating cell nuclear antigen had virtually disappeared, indicating persistent inhibition of mitotic cell activity. Morphological changes present included decreased olfactory cell numbers, loss of cells in areas just above basal cells and degeneration of the mucous layer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171440
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  • 4
    Electronic Resource
    Electronic Resource
    Age-related changes in dividing cells of the olfactory epithelium of the maturing guinea pig (1998)
    Springer
    European archives of oto-rhino-laryngology and head & neck 255 (1998), S. 289-292 
    Details
    ISSN: 1434-4726
    Keywords: Key words Olfactory epithelium ; Olfactory receptor ; cells ; Cell maturation ; Proliferating cell nuclear antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Changes in dividing cells of the olfactory epithelium from guinea pigs of different ages were examined by immunohistochemical staining using anti-proliferating cell nuclear antigen antibody. Numerous dividing cells were scattered diffusely in the basal layer of the olfactory epithelium at 1 and 2 months following birth and then gradually decreased with maturation until 4 months. Findings then remained constant between 4 and 24 months. Subsequently, cell numbers were found to decrease as animals became older. The number of olfactory receptor cells did not vary significantly between 1 and 30 months. Although no correlation could be found between the numbers of dividing cells and olfactory receptor cells, it is still possible that the longevity of the olfactory receptor cells changes to maintain the overall size of the neuronal population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004050050061
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  • 5
    Electronic Resource
    Electronic Resource
    Expressions of a calcium-binding protein (spot35/calbind in-D28k) in mouse olfactory cells: Possible relationship to neuronal differentiation (1997)
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. 105-109 
    Details
    ISSN: 1434-4726
    Keywords: Immunohistochemistry ; Olfactory epithelium ; Cell growth ; Proliferating cell nuclear antigen ; Olfaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We used immunohistochemistry to investigate the expression of spot35/calbindin-D28k (calbindin) in mouse olfactory epithelium during development. Cell stages of immunopositive olfactory cells were determined by comparing the levels of proliferating cell nuclear antigen (PCNA). Calbindin-positive cells were abundant in the middle layer of the epithelium of animals before 2 weeks of age and gradually diminished during development. Only low levels were detectable near the basement membrane in the adult. Changes of calbindin-positive cells in terms of number and distribution were apparently compatible with localization changes of premature olfactory cells. PCNA overlapped calbindin in the nasal mucosa at lower magnifications on stained serial sections and immunohistochemical double staining revealed that calbindin-mmunoreactive cells were located mainly just above PCNA-immunoreactive cells in the basal layer of the epithelium. This indicated that calbindin is expressed postmitotically in immatureolfactory cells and is lost by mature cells. These findings suggest that calbindin might support the maturation of the olfactory cells, such as the projection of the neuronal processes, by stabilizing intracellular calcium ions in immature cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01526190
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    Paper (German National Licenses)
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