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  • 1
    Electronic Resource
    Electronic Resource
    Effects of naloxone on methamphetamine and apomorphine stereotypy and on haloperidol catalepsy in rats (1984)
    Springer
    Psychopharmacology 82 (1984), S. 237-240 
    Details
    ISSN: 1432-2072
    Keywords: Naloxone ; Methamphetamine ; Apomorphine ; Haloperidol ; Stereotypy ; Catalepsy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pretreatment with the opiate antagonist naloxone, at 1.25–5 mg/kg, increased the intensity of methamphetamine stereotypy, had no effect (over a range of 0.3125–5 mg/kg) on apomorphine stereotypy, and antagonized haloperidol catalepsy in rats at 1.25–5 mg/kg. It is suggested that naloxone, by blocking the opiate receptors located on the nigro-striatal and mesolimbic dopamine (DA) nerve terminals, releases the DA systems from endogenous inhibition, presumably caused by endogenous opiate systems, and thereby potentiates methamphetamine stereotypy and antagonizes haloperidol catalepsy. However, the possibility that naloxone might have affected methamphetamine stereotypy and haloperidol catalepsy by modulating the activity of the central noradrenergic and GABAergic systems, which are reported to influence dopaminergically mediated behaviours, also needs to be considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427781
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of drugs influencing central serotonergic mechanisms on methamphetamine-induced stereotyped behavior in the rat (1979)
    Springer
    Psychopharmacology 64 (1979), S. 303-307 
    Details
    ISSN: 1432-2072
    Keywords: l-tryptophan ; Quipazine ; Clomipramine ; Methysergide ; Methamphetamine ; Stereotyped behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pretreatment with l-tryptophan, a precursor of serotonin, was found to decrease the intensity of stereotyped behavior induced by methamphetamine, while methysergide, a serotonin antagonist, was found to increase the intensity of methamphetamine-induced stereotyped behavior. These results suggest that the intensity of methamphetamine-induced stereotypy depends on the balance between central dopaminergic and serotonergic systems and that the central serotonergic system may have an opposing, tonic effect upon central dopaminergic systems involved in the mediation of stereotypy. In contrast to l-tryptophan, however, pretreatment with quipazine, a serotonin agonist, and clomipramine, a selective, serotonin neuronal uptake blocker, was found to potentiate the stereotyped behavior induced by methamphetamine. The probable mechanisms by which quipazine and clomipramine might have potentiated the methamphetamine-induced stereotypy are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427514
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effects of L-histidine and promethazine on apomorphine and amantadine stereotypy in rats (1983)
    Springer
    Psychopharmacology 79 (1983), S. 372-374 
    Details
    ISSN: 1432-2072
    Keywords: Apomorphine ; Amantadine ; Stereotyped behaviour ; L-Histidine ; Promethazine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pretreatment with L-histidine, a precursor of brain histamine, and promethazine, a H1 receptor blocker, failed to modify apomorphine-induced stereotyped behaviour in rats. In contrast, pretreatment with L-histidine significantly decreased the intensity of amantadine stereotypy while pretreatment with promethazine significantly increased the intensity of amantadine stereotypy in rats. The results suggest that drugs which influence central histaminergic mechanisms are effective only in modifying the stereotyped behaviour induced by the indirectly-acting DA agonist amantadine, and fail to modify the stereotyped behaviour induced by apomorphine, a directly-acting DA agonist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433422
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of drugs influencing central serotonergic mechanisms on haloperidol-induced catalepsy (1979)
    Springer
    Psychopharmacology 62 (1979), S. 67-69 
    Details
    ISSN: 1432-2072
    Keywords: Quipazine ; Clomiprimine ; Methysergide ; Haloperidol ; Catalepsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pretreatment with quipazine, a serotonin agonist, and clomipramine, a selective serotonin neuronal uptake blocker, was found to potentiate the cataleptic effect of haloperidol in a dose-dependent manner in rats. Pretreatment with methysergide, a serotonin antagonist, reduced the cataleptic effect of haloperidol. The results indicate that the cataleptic effect of neuroleptics depends on the balance between the dopaminergic and serotonergic systems, and that the serotonergic system exerts an inhibitory influence on the dopaminergic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426037
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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