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Digitale Medien

Inhibition of brain enolases by acrylamide and its related compounds in vitro, and the structure-activity relationship (1984)

Tanii, H. ; Hashimoto, K.

Springer

Cellular and molecular life sciences 40 (1984), S. 971-972

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ISSN: 1420-9071

Schlagwort(e): Rat brain ; Enolase ; acrylamide ; acrylamide derivatives ; neurotoxicity ; structure-activity relationship

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary Acrylamide and its related compounds inhibited brain enolases in vitro independently of their neurotoxicity. The inhibitory potency was a function of the binding constants of the compounds for phenylalanine. The binding constant for tryptophan was higher in neurotoxic compounds than in non-neurotoxic ones.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01946464

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Digitale Medien

Different responses of the isolated canine coronary artery superfused with blood or Krebs-Henseleit solution (1984)

Matsumoto, Y. ; Inui, J. ; Hashimoto, K.

Springer

Naunyn-Schmiedeberg's archives of pharmacology 327 (1984), S. 156-158

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ISSN: 1432-1912

Schlagwort(e): Canine coronary artery ; Superfusion media ; Nifedipine ; Ca2+-channels

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Responses of ring segments of the isolated canine coronary artery superfused with arterial blood from a donor dog were compared with responses of segments superfused with Krebs-Henseleit (K-H) solution. KCl (1–30 mg) caused contraction in a dose-dependent manner both in K-H solution- and in blood-superfused preparation. However, CaCl2 (1–100 mg) and nifedipine (0.1–30 μg) contracted and relaxed, respectively, only blood-superfused preparation but not K-H solution-superfused one. These results show that even in the same region of the coronary artery, different superfusates result in different responses to contracting or relaxing agents. This difference may be explained by the idea that Ca2+-channels are activated and endow basal tension in blood-superfused preparations, but not in K-H solution-superfused ones.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00500911

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Digitale Medien

Pulse response in an immobilized-enzyme column: Theoretical method for predicting elution curves (1980)

Adachi, S. ; Hashimoto, K. ; Matsuno, R. ; [weitere]

New York, NY [u.a.] : Wiley-Blackwell

Biotechnology and Bioengineering 22 (1980), S. 779-797

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ISSN: 0006-3592

Schlagwort(e): Chemistry ; Biochemistry and Biotechnology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: A theoretical method for predicting the elution profile of a pulse response in an immobilized-enzyme column is proposed. The method is based on a mass balance model, which is extensively used in gel chromatography. To test the method, a pulse of sucrose solution was applied to a column of spherical acrylamide gel in which was entrapped invertase from yeast, and it was eluted with 0.05M acetate buffer at pH 5.0. The elution curves of the substrate and the product were in fairly good agreement with the theoretically calculated ones. The method was extended to the system of reversible as well consecutive reactions.

Zusätzliches Material: 9 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bit.260220405

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