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  • 1
    Digitale Medien
    Digitale Medien
    α-Adrenoceptor-mediated inhibitory effect of the sympathetic nervous system on the isoprenaline-induced increase in plasma renin concentration (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 299 (1977), S. 77-82 
    Details
    ISSN: 1432-1912
    Schlagwort(e): α-Adrenoceptors ; Isoprenaline ; Renin ; Sympathetic nervous system
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The importance of the sympatho-adrenal system for the isoprenaline-induced increase in plasma renin concentration was investigated in conscious rats. Ganglionic blockade by trimethidinium (10 mg kg−1) increased the dose-dependent elevation of plasma renin concentration induced by isoprenaline (0.03–0.48 μg kg−1 min−1). Also treatment of the rats with guanethidine (6 mg kg−1) or reserpine (2.5 mg kg−1, given 16 and 7 h prior to the experiments) further increased the effect of isoprenaline (0.5 μg kg−1 min−1) on plasma renin concentration. Unilateral renal denervation combined with contralateral nephrectomy doubled the effect of the β-sympathomimetic amine on renin release. The α-adrenoceptor antagonist phenoxybenzamine (3 mg kg−1) also enhanced the effect of isoprenaline on this parameter. It is concluded that apart from a stimulation of renin release via β-adrenoceptors the sympathetic nervous system may inhibit renin release via stimulation of α-adrenoceptors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00508641
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  • 2
    Digitale Medien
    Digitale Medien
    Inhibitory effect of tyramine-induced release of catecholamines on renin secretion (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 303 (1978), S. 139-144 
    Details
    ISSN: 1432-1912
    Schlagwort(e): α-Adrenoceptors ; Renin ; Isoprenaline ; Tyramine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of the indirect sympathomimetic agent tyramine on the isoprenaline-induced increase in plasma renin concentration was investigated in conscious rats. Tyramine caused a dose-dependent decrease in the isoprenaline-induced elevation of plasma renin concentration. Pretreatment of the rats with reserpine abolished this effect of tyramine, indicating that tyramine released catecholamines which acted on the inhibitory adrenoceptors. Pretreatment with phenoxybenzamine, an α-adrenoceptor antagonist, also abolished the inhibitory effect of tyramine on renin release, indicating that α-adrenoceptors mediated the observed inhibition of renin release. In rats with chronically denervated kidneys tyramine did not inhibit renin release. It is concluded that catecholamines which are released from renal sympathetic nerve endings can suppress renin release by activating α-adrenoceptors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00508059
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  • 3
    Digitale Medien
    Digitale Medien
    Studies on the inhibitory effect of indomethacin and meclofenamate on the adrenalectomy-induced increase in plasma renin concentration (1979)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 309 (1979), S. 25-27 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Adrenalectomy ; Renin ; Indomethacin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Bilateral adrenalectomy combined with a sodium-deficient diet caused a time-dependent increase in plasma renin concentration in rats. Seventy-two hours after adrenalectomy the inhibitors of prostaglandin biosynthesis indomethacin and meclofenamate diminished the plasma renin concentration by about 50%. This effect was independent of the amount of renin released. Indomethacin and meclofenamate fully retained their ability to reduce the plasma renin concentration when the renal sympathetic nerves or the macula densa cells of the kidneys no longer contributed to renin release. It is concluded that in adrenalectomized rats renal prostaglandins affect the baroreceptor-mechanism in the afferent arterioles and thus enhance renin release.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00498753
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  • 4
    Digitale Medien
    Digitale Medien
    Inhibition of the adrenalectomy-induced increase in plasma renin concentration by vasoconstrictor agents in rats (1976)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 294 (1976), S. 187-192 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Adrenalectomy ; Renin ; Angiotensin II ; Felypressin ; Phenylephrine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Plasma renin concentrations in rats increase after bilateral adrenalectomy without sodium substitution. The effects of i.v. infused (asp1-β-amid, val5)-angiotensin II (1 μg/kg min), felypressin (phen2, lys8-vasopressin) (40 mU/kg min) and phenylephrine (30 μg/kg min) were investigated on the increase in plasma renin concentration. These effects of the agents were compared with their actions on blood pressure, heart rate and renal hemodynamics. In rats with destroyed macula densa cells the effect of bilateral adrenalectomy without sodium substitution was also studied. Adrenalectomy still increased the plasma renin concentration. Angiotensin II and felypressin, also depressed under these conditions the elevation of plasma renin concentration caused by adrenalectomy. The mechanism of the adrenalectomy-induced reinin release and its suppression by vasoconstrictor agents is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00507852
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  • 5
    Digitale Medien
    Digitale Medien
    Suppression of isoprenaline-induced increase in plasma renin concentration by vasoconstrictors in rats with nonfunctioning Macula densa (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 315-321 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Isoprenaline ; Renin ; Vasoconstrictors ; Macula densa
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The mechanism of the increase in plasma renin concentration caused by the β-sympathomimetic agent isoprenaline has been further investigated. Rats were pretreated by occluding the left renal artery for 2 hrs, thus rendering the macula densa cells of this kidney nonfunctioning. After contralateral nephrectomy infusion of isoprenaline (1.5 μg/kg min) still caused a strong increase in plasma renin concentration. This increase was significantly suppressed by simultaneous infusion of angiotensin II (1.0 μg/kg min), the α-sympathomimetic amine phenylephrine (60 μg/kg min) or octapressin (10 mU/kg min). The results exclude any mediator-role of the macula densa receptors in the isoprenaline-induced release of renin. The possibility of a stimulation of renin release via the baroreceptors or a direct “secretomotoric” action of isoprenaline is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00510560
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