ISSN:
1573-4919
Keywords:
DNA topoisomerase I
;
camptothecin
;
αA-globin gene
;
c-Ha-ras gene
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Two molecular forms of topoisomerase I differing in size and sensitivity to camptothecin were isolated from calf thymus. Mapping of topo I cleavage sites of the cloned chicken αA-globin and human c-Ha-ras genes was carried out. Camptothecin was shown to affect site specificity of the topoisomerases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00229529
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