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  • Engineering General  (3)
  • Endotoxin  (2)
  • Rheumatoid arthritis  (2)
  • 87.60 Gp  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Relation of clinical activity of rheumatoid arthritis to immune complexes, complement components and anti-immunoglobulins (1984)
    Springer
    Rheumatology international 4 (1984), S. 159-163 
    Details
    ISSN: 1437-160X
    Schlagwort(e): Rheumatoid arthritis ; Immune complexes ; Anti-immunoglobulin ; Complement
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Circulating immune complexes by fluid phase Clq binding assay, complement components and anti-immunoglobulin levels were studied in sera of 35 patients with rheumatoid arthritis (RA). In 23 of the 35 sera (65.7%), circulating immune complexes were positive, and the mean±SD of Clq binding activity (ClqBA), 44.5±19.4%, was significantly high compared to that of healthy persons, 17.4±8.2%. Antigenic determination of complement components revealed that Clq, C3, C5, C9, factor B and Cl esterase inhibitor (CIINH) were significantly high in sera of RA, but C4 and properdin were not. The disease activity correlated with ClqBA, IgG- and IgM-anti-immunoglobulins, C9 and serum IgG. On the other hand, ClqBA correlated with both IgG- and IgM-anti-immunoglobulin levels but not with complement components.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00541207
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  • 2
    Digitale Medien
    Digitale Medien
    Two-dimensional coherent detection imaging in multiple scattering media based on the directional resolution capability of the optical heterodyne method (1991)
    Springer
    Applied physics 52 (1991), S. 391-394 
    Details
    ISSN: 1432-0649
    Schlagwort(e): 42.60.Kg ; 87.60 Gp
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract This paper describes a new application of optical heterodyne detection using a laser beam for two-dimensional imaging of the internal structure of strongly scattering media in which the structure is completely obstructed from normal visual observation. The directional resolution capability for image formation due to the excellent antenna properties of the heterodyne technique is verified experimentally using a ground glass to cause strong scattering of the signal beam. Successful image detection of a test target placed in a highly scattering absorptive medium, with spatial resolution better than 400 μm in the case of our experiments, demonstrates that this Coherent Detection Imaging (CDI) method can overcome the diffuse nature of images in media such as those of biomedical interest and others to achieve scanning and tomographic imaging.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00325156
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  • 3
    Digitale Medien
    Digitale Medien
    Lipopolysaccharide-induced colitis in rabbits (1986)
    Springer
    Research in experimental medicine 186 (1986), S. 61-69 
    Details
    ISSN: 1433-8580
    Schlagwort(e): Experimental colitis ; Rabbits ; Lipopolysaccharide ; Endotoxin ; Tissue fibrinolysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary An experimental animal model of human ulcerative colitis using lipopolysaccharide (LPS) was studied. Rabbits were skin-sensitized by LPS and challenged with intrarectal instillation of LPS after 1% formalin enema. The course of experimental colitis was followed by performing serial colonofiberscopic examinations and biopsy. Petechiae appeared from the 8th hour, and ulcers and bleeding on the 3rd day. Mild macroscopic changes continued for about 2 weeks. By repeating the LPS enema after the initial treatment, the colitis was maintained for over 1 month. Control groups without formalin enema revealed no macroscopic changes, and the groups with only formalin enema showed mild transient changes. The endotoxin level in the blood during the experiment increased (36 pg/ml) at 24 h after the treatment in the LPS-sensitized group, while non-sensitized control rabbits had higher levels of endotoxin. Though fibrinogen and PTT levels had increased at 24 and 72 h, these levels were more marked in the control rabbits. The direct reaction of LPS was minimal, and local immune reaction by LPS seems to play an important role in the perpetuation of experimental colitis. Tissue fibrinolysis of the colon increased significantly as the mucosal damage appeared. This experimental colitis with LPS may be useful as a model of human ulcerative colitis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01851834
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  • 4
    Digitale Medien
    Digitale Medien
    Experimental model of disseminated intravascular coagulation induced by sustained infusion of endotoxin (1981)
    Springer
    Research in experimental medicine 179 (1981), S. 223-228 
    Details
    ISSN: 1433-8580
    Schlagwort(e): Disseminated intravascular coagulation (DIC) ; Endotoxin ; Rats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Experimental disseminated intravascular coagulation (DIC) was induced by sustained infusion of endotoxin into the femoral vein in rats. The severity of DIC was determined with reference to various parameters, such as fibrinogen and fibrin degradation products (FDP), prothrombin time (PT), partial thromboplastin time (PTT), platelet count, and number of renal glomeruli having fibrin thrombi. Experimental DIC could be induced by a 4-h sustained infusion of endotoxin in a dose of 100 mg/kg. The DIC induced in rats showed a close resemblance to human DIC as judged from such changes as an elevation in FDP, prolongation of PT and PTT, depression in fibrinogen and platelet count, and increase in glomeruli having fibrin thrombi. This experimental model has an advantage in that the severity of DIC can be determined by measuring various parameters. It will be of use in the studies aimed at the establishment of a therapy for DIC as well as in the studies on DIC in rats.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01851619
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  • 5
    Digitale Medien
    Digitale Medien
    Quantification of bone volume on radiographs using NIH Image (2000)
    Springer
    Modern rheumatology 10 (2000), S. 220-224 
    Details
    ISSN: 1439-7609
    Schlagwort(e): Key words Radiograph ; Rheumatoid arthritis ; Bone volume ; NIH Image ; Computer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We attempted to quantify periarticular bone atrophy from radiographs of the proximal phalanx in patients with rheumatoid arthritis (RA) by means of the National Institutes of Health (NIH) Image computer program. The degree of brightness or darkness in four squares, each 20 × 20 pixels, in the right third proximal phalanx was measured using NIH Image, and the mean value of the 400 pixels was defined as the brightness/darkness index (BDI). The BDI was used to express bone volume. The BDI value was set at zero for an area of complete darkness and at 255 for an area of maximum brightness. The mean coefficient of variation in our hospital was 2.28%. The BDI was measured in 54 RA patients and 146 normal volunteers. The mean BDI at the midpoint of the diaphysis was 100 in RA patients and 176 in normal volunteers, while at the medial side of the proximal end it was 75 and 145, respectively. The difference between normal volunteers and RA patients was greatest in younger people. In some young RA patients, the BDI was significantly low at the medial side of the proximal end, clearly demonstrating periarticular bone atrophy. Periarticular bone atrophy can be quantified using the NIH Image computer program.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s101650070006
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  • 6
    Digitale Medien
    Digitale Medien
    Stresses for an elastic half-space under a tilted rigid rectangular footing (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 6 (1982), S. 483-490 
    Details
    ISSN: 0363-9061
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geologie und Paläontologie
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nag.1610060408
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  • 7
    Digitale Medien
    Digitale Medien
    Some suggestions for the finite element analysis of two-dimensional elasto-plastic stress concentrations (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Communications in Applied Numerical Methods 3 (1987), S. 115-122 
    Details
    ISSN: 0748-8025
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cnm.1630030207
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  • 8
    Digitale Medien
    Digitale Medien
    A simple substructuring procedure for finite element analysis of stress concentrations (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Communications in Applied Numerical Methods 1 (1985), S. 215-218 
    Details
    ISSN: 0748-8025
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cnm.1630010506
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