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  • Systemic lupus erythematosus  (3)
  • Plasmin  (1)
  • Rhodobacter sphaeroides  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Clinical significance of U1-RNP immune complexes in mixed connective tissue disease and systemic lupus erythematosus (1987)
    Springer
    Rheumatology international 7 (1987), S. 7-11 
    Details
    ISSN: 1437-160X
    Keywords: U1-ribonucleoprotein ; Immune complexes ; Mixed connective tissue disease ; Systemic lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We measured U1-RNP: anti-U1-RNP immune complexes (U1-RNP ICs) in patients with mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE) to examine the clinical significance of circulating U1-RNP ICs. The level of U1-RNP ICs in 11 patients with MCTD was significantly higher than that in 22 normal subjects and there was a close correlation between the level of U1-RNP ICs and the clinical disease activity index of MCTD. In contrast, the level of U1-RNP ICs in 31 patients with SLE was not significantly higher than that in normal subjects and that was not correlated with the clinical disease activity index of SLE or the renal histologic activity index of lupus nephritis. We conclude that U1-RNP ICs are present in sera of patients with MCTD and SLE, and that the level of U1-RNP ICs may be closely associated with clinical disease activity in patients with MCTD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00267336
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Plasminogen activation in plasma of patients with systemic lupus erythematosus (1989)
    Springer
    Rheumatology international 8 (1989), S. 273-277 
    Details
    ISSN: 1437-160X
    Keywords: Plasminogen activation ; Plasmin ; α2-Plasmin inhibitor ; Complements ; Systemic lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We measured α2-plasmin inhibitor-plasmin complexes (PI-PC) in plasma of patients with systemic lupus erythematosus (SLE) to examine the plasminogen activation in SLE. The plasma PI-PC level in 23 patients with SLE was significantly higher than that in 18 normal subjects (P〈0.001) and the SLE patients with nephrotic syndrome had higher plasma PI-PC levels than those without nephrotic syndrome (P〈0.01). In addition, the plasma PI-PC level was significantly correlated with the level of plasma C3 breakdown products (iC3b/C3dg) in the patients with SLE (r=0.53, P〈0.01). These results suggest that plasminogen is activated in plasma of patients with SLE and that the plasminogen activation may be associated with the activation of complement in SLE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270984
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Differential diagnosis of fever in systemic lupus erythematosus using discriminant analysis (1986)
    Springer
    Rheumatology international 6 (1986), S. 69-77 
    Details
    ISSN: 1437-160X
    Keywords: Systemic lupus erythematosus ; Fever ; Serum globulin fractions ; Discriminant analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In an attempt to find a reliable method to assess fever in patients with systemic lupus erythematosus (SLE), a multifactorial analysis was applied to the routine laboratory examinations, including white blood cell count (WBC) and serum globulin fraction concentrations. During 74 febrile episodes, 49 SLE patients showed increased disease activity and the remaining 25 febrile episodes were due to intercurrent infection. The two different groups of fever episodes were clearly separated by a principal component analysis using five variables from the routine laboratory tests, including WBC, serum alpha-1, alpha-2, beta, and gamma globulins. Discriminant analysis showed that 95% of 74 febrile episodes could be correctly classified as to the cause of fever when a combination of WBC and alpha-2 globulin level was used as variables. A simple discriminant formula which we calculated was considered to be of practical use for the differentiation of the two clinical entities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541508
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A puhA gene deletion and plasmid complementation system for facile site directed mutagenesis studies of the reaction center H protein of Rhodobacter sphaeroides (1998)
    Springer
    Photosynthesis research 55 (1998), S. 369-373 
    Details
    ISSN: 1573-5079
    Keywords: complementation ; deletion ; puhA gene ; reaction center H protein ; Rhodobacter sphaeroides ; site directed mutagenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We describe the development of a Rhodobacter sphaeroides RC H (puhA) gene deletion/plasmid complementation system for expression of site directed mutants of the RC H protein. The mutant strain ΔPUHA was constructed by introduction of a translationally in-frame deleted puhA allele at the chromosomal puhA gene site, and evaluated in plasmid complementation experiments. Strain ΔPUHA was not capable of photosynthetic growth, and SDS-PAGE chromatophore proteins confirmed the absence of the RC H protein band. When ΔPUHA was complemented with the wild type puhA gene in plasmids, photosynthetic growth and the RC H protein band in SDS-PAGE were restored. The results of comparisons of the properties of strains with different types of chromosomal puhA gene disruptions in complementation experiments with plasmid-borne DNA fragments containing the wild type puhA gene are consistent with the idea that expression of one or more genes located 3′ of puhA is required for optimal RC levels and photosynthetic growth. Since the ΔPUHA translationally in frame deletion does not seem to interfere with transcription through and beyond the residual puhA sequences, this strain allows facile evaluation of the consequences of plasmid-borne RC H mutations in an otherwise wild type genetic background. Two plasmid-borne site directed mutants of the puhA gene (GluH173 → Gln and GluH173 → Asp) exhibited different deficiencies in photosynthetic growth when present in ΔPUHA, indicating that a carboxylic acid amino acid side chain at the H173 position is important for RC function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005983903558
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    Paper (German National Licenses)
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