ISSN:
1573-2568
Keywords:
BIOMECHANICS
;
DOSE-RESPONSE RELATIONSHIP
;
LONGITUDINAL STUDIES
;
SCLEROTHERAPY
;
SWINE
;
WALL TENSION
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The dose- and time-dependent effects ofendoscopic sclerotherapy on luminal cross-sectional areaand wall distensibility were studied in pigs at 5 and 12cm proximal to the gastroesophageal junction by means of impedance planimetry. Sixteen healthyanimals underwent two sessions of endoscopicsclerotherapy two weeks apart with injections of either5 or 10 ml of 1% Polidocanol in the distal 7 cm of the esophagus each time. The animals wereinvestigated before sclerotherapy, two weeks after eachsession, and finally six weeks after the last session.Six healthy animals were studied as controls. Endoscopic sclerotherapy caused luminal narrowing in thesclerosed zone followed by normalization six weeks afterthe last treatment (P 〈 0.05 in both groups). Walldistensibility decreased in the sclerosed zone after treatment with 10 ml sclerosant (P 〈0.05) followed by partial normalization, while no effectwas found after 5 ml sclerosant (P 〉 0.2).Progressive dilations were observed in the proximalesophagus in both groups and were most pronounced in the10 ml group (P 〈 0.05). Wall distensibility did notchange proximal to the site of sclerotherapy in eithergroup (P 〉 0.1).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018802922374
Permalink
