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  • 1
    Electronic Resource
    Electronic Resource
    Lactate dehydrogenase and glutamate dehydrogenase activities in the circumventricular organs of rat brain following neonatal monosodium glutamate (1993)
    Springer
    Cellular and molecular life sciences 49 (1993), S. 1092-1094 
    Details
    ISSN: 1420-9071
    Keywords: Monosodium glutamate ; LDH ; GDH ; excitotoxin ; blood-brain barrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Glutamate (glu) an excitatory neurotransmitter amino acid, is present in high concentrations in the mammalian central nervous system and is the most abundant amino acid in our daily diet. In the present study the activities of lactate dehydrogenase (LDH) and glutamate dehydrogenase (GDH) were evaluated in the circumventricular organs (CVO) of the brain in 25-day-old rats following MSG administration at a dose of 4 mg/g b.wt during the first ten days of life. The results show the LDH activity increased to 265% of that in the control (p〈0.001), whereas GDH activity was significantly decreased (p〈0.05), The great elevation in LDH, a cytoplasmic marker enzyme, is apparently due to cytoskeletal changes brought about as a consequence of glu toxicity, whereas lowered GDH activity indicates altered glu homostasis in the blood-brain-barrier deficient areas following neonatal exposure to glu.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01929919
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Microangioarchitecture of the islets of Langerhans in the snakes,Naja naja, Vipera russelli, andEchis carinatus (1991)
    Springer
    Cell & tissue research 266 (1991), S. 83-88 
    Details
    ISSN: 1432-0878
    Keywords: Islets of Langerhans ; Microangioarchitecture ; Corrosion casts ; Scanning electron microscopy ; Naja naja, Vipera russelli, Echis carinatus (Serpentes)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Due to a decided lack in the literature of reports on the microangioarchitecture of the pancreas of snakes, an analysis was performed in three different species of two different ophidian families with the use of cast preparations and complementary scanning electron microscopy. The vascular architecture reflects the lobular substructure of the pancreas; the organ is supplied by branches of the superior mesentric artery. Coiled lobular arteries and arterioles continue into a meshwork of capillaries. Dilated capillaries of the endocrine portion of the pancreas are an integral component of this fine capillary network. A few very small capillaries establish a connection between the endocrine and the exocrine pancreas. The other capillaries drain into venules, which ultimately join their respective veins. No interspecific differences were noted in the vascularization of the pancreas of the three ophidian species examined. The present results suggest the existence of arterio-venous anastomoses and speak against the presence of a portal system, but establish a feed-forward capillary connection from the endocrine to the exocrine component of the ophidian pancreas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00678714
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    Paper (German National Licenses)
    Fulltext
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