ISSN:
1432-0533
Keywords:
Scrapie
;
Fibrils
;
Amyloid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Abnormal fibrillary structures, designated “scrapie-associated fibrils” (SAF), have been observed using negative stain techniques in subfractions of brains from scrapie-affected animals. SAF have been observed in all combinations of strain of scrapie agent and strain or species of host examined, regardless of their histopathology, in particular the presence or absence of amyloid plaques. SAF consist either of two or four filaments. They are morphologically dissimilar to the normal brain fibrils — microtubules, neurofilaments, glial filaments, and F actin. However, SAF do bear a resemblance to amyloid.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00691333
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