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  • Electronic Resource  (5)
  • Systemic lupus erythematosus  (3)
  • Anxiety  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Regional changes in dopamine and serotonin activation with various intensity of physical and psychological stress in the rat brain
    Amsterdam : Elsevier
    Pharmacology, Biochemistry and Behavior 49 (1994), S. 911-920 
    Details
    ISSN: 0091-3057
    Keywords: Anxiety ; Conditioned fear stress ; Dopamine ; Footshock stress ; Freezing behavior ; Medial prefrontal cortex ; Psychological stress ; Serotonin ; Stress intensity
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0091-3057(94)90243-7
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats (1996)
    Springer
    Psychopharmacology 123 (1996), S. 182-186 
    Details
    ISSN: 1432-2072
    Keywords: Anxiety ; Conditioned fear stress ; Freezing behavior ; Serotonin reuptake inhibitors ; Citalopram ; Fluvoxamine ; Milnacipran
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Conditioned fear stress (CFS)-induced freezing behavior has been proposed as an animal model of anxiety. In the present study, freezing was used to determine the anxiolytic activity of selective serotonin reuptake inhibitors (SSRIs), which are reported to be clinically effective in anxiety disorders. The duration of freezing behavior was reduced by acute treatment with the SSRIs citalopram (1–10 mg/kg) and fluvoxamine (3–30 mg/kg). Acute treatment with the serotonin (5-HT)/noradrenaline (NA) mixed reuptake inhibitor milnacipran (3–30 mg/kg) also attenuated CFS-induced freezing, while acute treatment with the NA reuptake inhibitors maprotiline and ORG4428, and the dopamine (DA) reuptake inhibitor GBR12909 failed to alter CFS-induced freezing. These results indicate that facilitation of 5-HT availability in the brain produced by 5-HT reuptake inhibition reduces CFS-induced freezing behavior. CFS may be a useful model for detecting the anxiolytic potential of 5-HT reuptake inhibitors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246175
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical significance of U1-RNP immune complexes in mixed connective tissue disease and systemic lupus erythematosus (1987)
    Springer
    Rheumatology international 7 (1987), S. 7-11 
    Details
    ISSN: 1437-160X
    Keywords: U1-ribonucleoprotein ; Immune complexes ; Mixed connective tissue disease ; Systemic lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We measured U1-RNP: anti-U1-RNP immune complexes (U1-RNP ICs) in patients with mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE) to examine the clinical significance of circulating U1-RNP ICs. The level of U1-RNP ICs in 11 patients with MCTD was significantly higher than that in 22 normal subjects and there was a close correlation between the level of U1-RNP ICs and the clinical disease activity index of MCTD. In contrast, the level of U1-RNP ICs in 31 patients with SLE was not significantly higher than that in normal subjects and that was not correlated with the clinical disease activity index of SLE or the renal histologic activity index of lupus nephritis. We conclude that U1-RNP ICs are present in sera of patients with MCTD and SLE, and that the level of U1-RNP ICs may be closely associated with clinical disease activity in patients with MCTD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00267336
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Plasminogen activation in plasma of patients with systemic lupus erythematosus (1989)
    Springer
    Rheumatology international 8 (1989), S. 273-277 
    Details
    ISSN: 1437-160X
    Keywords: Plasminogen activation ; Plasmin ; α2-Plasmin inhibitor ; Complements ; Systemic lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We measured α2-plasmin inhibitor-plasmin complexes (PI-PC) in plasma of patients with systemic lupus erythematosus (SLE) to examine the plasminogen activation in SLE. The plasma PI-PC level in 23 patients with SLE was significantly higher than that in 18 normal subjects (P〈0.001) and the SLE patients with nephrotic syndrome had higher plasma PI-PC levels than those without nephrotic syndrome (P〈0.01). In addition, the plasma PI-PC level was significantly correlated with the level of plasma C3 breakdown products (iC3b/C3dg) in the patients with SLE (r=0.53, P〈0.01). These results suggest that plasminogen is activated in plasma of patients with SLE and that the plasminogen activation may be associated with the activation of complement in SLE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270984
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Differential diagnosis of fever in systemic lupus erythematosus using discriminant analysis (1986)
    Springer
    Rheumatology international 6 (1986), S. 69-77 
    Details
    ISSN: 1437-160X
    Keywords: Systemic lupus erythematosus ; Fever ; Serum globulin fractions ; Discriminant analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In an attempt to find a reliable method to assess fever in patients with systemic lupus erythematosus (SLE), a multifactorial analysis was applied to the routine laboratory examinations, including white blood cell count (WBC) and serum globulin fraction concentrations. During 74 febrile episodes, 49 SLE patients showed increased disease activity and the remaining 25 febrile episodes were due to intercurrent infection. The two different groups of fever episodes were clearly separated by a principal component analysis using five variables from the routine laboratory tests, including WBC, serum alpha-1, alpha-2, beta, and gamma globulins. Discriminant analysis showed that 95% of 74 febrile episodes could be correctly classified as to the cause of fever when a combination of WBC and alpha-2 globulin level was used as variables. A simple discriminant formula which we calculated was considered to be of practical use for the differentiation of the two clinical entities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541508
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    Paper (German National Licenses)
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