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  • 1980-1984  (2)
  • Dog  (1)
  • Trophoblastic tumours  (1)
Materialart
Erscheinungszeitraum
  • 1980-1984  (2)
Jahr
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Journal of cancer research and clinical oncology 97 (1980), S. 51-62 
    ISSN: 1432-1335
    Schlagwort(e): Gastric carcinoma ; Dog ; MNNG ; Endoscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Serial studies by endoscopy and biopsy were made in a Beagle dog during and after oral administration of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). Between the 23rd and the 45th week of observation erosions and ulcers appeared at the angulus of the stomach and turned into ulcer scar. A depression with atypical glands was seen in the ulcer scar of the posterior wall of the angulus at the 94th week. It developed elevated margins at the 102nd week, when a well differentiated adenocarcinoma was found histopathologically. Ulceration and reepithelialization were observed in the early carcinoma. The carcinoma progressed into a larger one of Borrmann's type 2 at the 115th week and further into its type 3 at the 181st week. A second carcinoma with signet ring cell carcinoma developed in the anterior wall of the angulus. The two carcinomas fused and formed a single lesion. At autopsy in the 216th week the carcinoma invaded the serosa, and metastasis to regional lymph nodes was observed.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-0711
    Schlagwort(e): Pregnancy-specific ß-glycoprotein (SP1) ; ß-hCG ; Urinary hCG ; Trophoblastic tumours
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Using immunological techniques urinary hCG, pregnancy-specific ß-glycoprotein (SP1) and ß-subunit of hCG (ß-hCG) levels were measured in the serum and cerebrospinal fluid of patients with trophoblastic tumours. After removal of hydatidiform moles, urinary hCG, ß-hCG and SP1 levels were similar, but SP1 levels tended to exceed serum ß-hCG levels. SP1 usually disappeared first. In patients with metastatic choriocarcinoma, SP1 levels appeared to be lower than ß-hCG values in serum and cerebrospinal fluid, but urinary hCG, ß-hCG and SP1 concentrations all decreased during chemotherapy. Measurements of SP1 levels may well be useful in the monitoring of patients being treated for trophoblastic tumours.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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