ISSN:
1432-1335
Keywords:
Alkyl-lysophospholipids
;
Malignant hypernephroma
;
Tumor growth inhibition in vitro
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Synthetic alkyl-lysophospholipids (ALPs) inhibit the proliferation of human hypernephromas in vitro. Cells of ten different tumors were incubated with 4 ALPs for periods of more than 24 h. Eight of ten cell lines showed proliferation rates below 1% of the controls after cultivation. One microgram of ALPs per 106 tumor cells was effective, in some experiments a dose response relation was found for even lower concentrations. Equivalent concentrations of cytostatic drugs did not show reproducible higher antitumor effects in vitro. In two of the tested cell lines ALPs did not show any reproducible tumor growth inhibition, whereas at least some of the cytostatic drugs revealed slight cytostatis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00410118
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