ISSN:
1432-0738
Keywords:
Key words Monoclonal antibodies
;
Competitive inhibition enzyme immunoassay
;
Vx
;
Detection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Two monoclonal antibodies (Vx-BB8 and Vx-EA11) to the chemical warfare agent Vx were produced and characterized. A competitive inhibition enzyme immunoassay was developed to detect Vx concentrations as low as 3.7×10-7–3.7×10-6 mol/l in biological samples. Vx-BB8 400 μg given intravenously immediately before 1×LD95 Vx or 400 μg Vx-BB8 intraperitoneally 1.5 h–3 days before 1×LD95 Vx could protect all the tested mice from death.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002040050213
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