ISSN:
1617-4623
Keywords:
Drosophila
;
Enhancer of split
;
achaete-scute
;
Helix-loop-helix proteins
;
Protein-protein interactions
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract TheEnhancer of split andachaete-scute gene complexes [E(spl)-C and AS-C] encode helix-loop-helix proteins required for neurogenesis inDrosophila. Using a heterologous bacterial system, we show that (i) the bHLH domains of the proteins encoded by the two gene complexes differ in their ability to form homo- and/or heterodimers; (ii) the bHLH domains of the E(spl)-C proteins m5, m7 and m8 interact with the bHLH domains of the Ac and Sc proteins. These bHLH domains form an interaction network which may represent the molecular mechanism whereby the competent state of the proneural cells is maintained until the terminal determination to neuroblast occurs. Also, the pattern of interactions of the bHLH domains of certain proteins encoded by the two gene complexes may explain their functional redundancy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02174111
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