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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 40 (1991), S. S77 
    ISSN: 1432-1041
    Keywords: Atherosclerosis ; lipid peroxidation ; antioxidants ; probucol ; WHHL rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Probucol has been used as a lipid-lowering agent for over 10 years. Lately it has been found that its antiatherogenic action is due mainly to its antioxidative capacity, in addition to its known lipid-lowering effect. To study the antioxidative capability of probucol and its influence on plaque developement we used the animal model of the LDL-receptor-defective Watanabe heritable hyperlipidemic (WHHL) rabbit. In this study we measured all lipid values before and after probucol feeding and compared them with corresponding values in untreated controls. Probucol levels were determined, as were the physiological antioxidants alpha and gamma tocopherol (vitamin E). Thiobarbituric reactive substances were measured in plasma as a parameter for lipid peroxidation. In addition to the biochemical measurements the plaque area was analyzed macroscopically and microscopically to check the antiatherosclerotic effect and correlate it with the biochemical parameters. In four experiments we showed that probucol treatment in WHHL rabbits decreases the progression of atherosclerotic plaques by way of a combined lipid-lowering and antioxidative effect.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 364 (1984), S. 526-526 
    ISSN: 1435-2451
    Keywords: Arterial occlusive disease ; Deep femoral artery ; Limb salvage ; Peripheres arterielles Verschlu\leiden ; A. profunda femoris ; Extremitiitenerhaltung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vom 1. 10. 1977 bis 31. 12. 1983 wurden 269 rekonstruktive Eingriffe an der A. profunda femoris vorgenommen, davon 16mal als sog. femoroprofundaler Bypass, d. h. als Bypass von der A. femoralis communis zur peripheren A. profunda femoris. Es handelte sich um Patienten mit amputationsgefdhrdeten Extremitäten (AVL III und IV), um Patienten mit AVL IIb mit erheblichem OP-Risiko und zum Rezidiveingriffe in der Leiste. Bei 53,9% der Patienten trat eine Verbesserung des AVL ein, bei 26,9% konnte keine Besserung erzielt werden. 2 Patienten mußten Oberschenkel-und 1 Patient Unterschenkel-amputiert werden. Damit bietet der femoro-profundale Bypass eine Alternative zur großen Gliedmaßenamputation.
    Notes: Summary From 1 October 1977 to 31 December 1983, 269 reconstructive operations on the deep femoral artery were done, 26 of them as a femoroprofundal bypass, i.e., a bypass from the common femoral artery to the distal A. profunda femoris. Twenty-four patients had occlusive disease stage III or IV with imminent amputation, 2 had stage II with poor risk, and 16 had had one or more previous operations in the groin. There was improvement in the occlusive disease in 53.9% and no change in 26.9%; two amputations of the upper and one of the lower limb had do be performed. Two patients died postoperatively. The femoroprofundal bypass is a limb-saving procedure in peripheral arterial occlusive disease.
    Type of Medium: Electronic Resource
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